caa a22 4500 467985758 CHVBK 20180323112531.0 cr unu---uuuuu 170328e19901001xx s 000 0 eng 10.1007/BF00194223 doi (NATIONALLICENCE)springer-10.1007/BF00194223 Significance of structural chromosome aberrations in human sperm: analysis of induced aberrations [Elektronische Daten] [A. Genescá, J. Benet, M. Caballín, R. Miró, J. Germá, J. Egozcue] Summary: A significant increase in the incidence of structural chromosome anomalies has been observed in the sperm of patients treated with radio and/or chemotherapy for different types of cancer when analyzed by the interspecific fertilization of hamster eggs. The analysis of these aberrations shows that while in controls only 9.4% of structural abnormalities are of the stable type, in treated patients this figure increases to 39.3%, thus indicating that the anomalies have not been produced during the fertilization of the hamster egg. However, it is possible that part, or even most, of the breaks appear as a result of a reduced repair capacity of sperm chromosomes in the cytoplasm of the hamster egg. Springer-Verlag, 1990 Genescá A. Departament de Biologia Cel.lular i Fisiologia, Facultat de Medicina, Universitat Autónoma de Barcelona, E-08193, Bellaterra, Spain aut Benet J. Departament de Biologia Cel.lular i Fisiologia, Facultat de Medicina, Universitat Autónoma de Barcelona, E-08193, Bellaterra, Spain aut Caballín M. Departament de Biologia Animal, Biologia Vegetal i Ecologia, Universitat Autónoma de Barcelona, E-08193, Bellaterra, Spain aut Miró R. Departament de Biologia Cel.lular i Fisiologia, Facultat de Medicina, Universitat Autónoma de Barcelona, E-08193, Bellaterra, Spain aut Germá J. Servei d'Oncologia, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, E-08193, Bellaterra, Spain aut Egozcue J. Departament de Biologia Cel.lular i Fisiologia, Facultat de Medicina, Universitat Autónoma de Barcelona, E-08193, Bellaterra, Spain aut Human Genetics Springer-Verlag 85/5(1990-10-01), 495-499 0340-6717 85:5<495 1990 85 439 https://doi.org/10.1007/BF00194223 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00194223 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Genescá A. Departament de Biologia Cel.lular i Fisiologia, Facultat de Medicina, Universitat Autónoma de Barcelona, E-08193, Bellaterra, Spain aut NATIONALLICENCE 700 1- Benet J. Departament de Biologia Cel.lular i Fisiologia, Facultat de Medicina, Universitat Autónoma de Barcelona, E-08193, Bellaterra, Spain aut NATIONALLICENCE 700 1- Caballín M. Departament de Biologia Animal, Biologia Vegetal i Ecologia, Universitat Autónoma de Barcelona, E-08193, Bellaterra, Spain aut NATIONALLICENCE 700 1- Miró R. Departament de Biologia Cel.lular i Fisiologia, Facultat de Medicina, Universitat Autónoma de Barcelona, E-08193, Bellaterra, Spain aut NATIONALLICENCE 700 1- Germá J. Servei d'Oncologia, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, E-08193, Bellaterra, Spain aut NATIONALLICENCE 700 1- Egozcue J. Departament de Biologia Cel.lular i Fisiologia, Facultat de Medicina, Universitat Autónoma de Barcelona, E-08193, Bellaterra, Spain aut NATIONALLICENCE 773 0- Human Genetics Springer-Verlag 85/5(1990-10-01), 495-499 0340-6717 85:5<495 1990 85 439 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer