caa a22 4500 467985839 CHVBK 20180323112531.0 cr unu---uuuuu 170328e19901001xx s 000 0 eng 10.1007/BF00194235 doi (NATIONALLICENCE)springer-10.1007/BF00194235 Chromosomal aberrations in patients with primary biliary cirrhosis [Elektronische Daten] [Arman Notghi, Ursula Nestle, Gabriele Rittner, Pierre Brissot, Herve Jouanolle, Michael Manns, Engelhardt Schleiermacher, Christian Rittner] Summary: Chromosomal aberrations in untreated lymphocyte cultures, bleomycin (BLM)-induced aberrations and sister chromatid exchanges (SCE) in the peripheral blood lymphocytes of 11 patients suffering from primary biliary cirrhosis (PBC) and 14 matched control individuals were analysed. The lymphocytes of the PBC patients had on average a lower mitotic index (2.3) compared with controls (3.5) in the untreated cultures. The mean baseline rate of aberrations of the cultured lymphocytes of the patients was 5.3 aberrations per 100 metaphases (%); this was significantly different (P=0.0291) from that of the controls with a mean of 2.3%. In lymphocytes of the patients and controls, most of the aberrations observed took the form of gaps; there was an almost equal breakage rate in both groups (0.5% and 0.4%, respectively). The average number of mitoses with aberrations in the PBC patients studied was double that of the controls (4.9% and 2.3% respectively, P=0.0323). The mean number of the BLM-induced aberrations was 54.0% and 27.7% for the lymphocytes of the patients and controls, respectively. The mean number of the aberrant mitoses in the BLM cultures was 6 times higher than that of the untreated cultures for both groups, 25.7% and 14.6% respectively (P=0.018). The chromosomal distribution of baseline and induced aberrations was not random. The PBC patients had a mean number of 8.7 SCE per mitosis, which was significantly higher than the SCEs in the controls (6.3 SCE per mitosis; P=0.0156). The evidence suggests that the chromosomes of the lymphocytes of PBC patients may be less stable than those of the control individuals in this study. Springer-Verlag, 1990 Notghi Arman Institut für Rechtsmedizin der Universität, Am Pulverturm 3, D-6500, Mainz, Federal Republic of Germany aut Nestle Ursula Institut für Rechtsmedizin der Universität, Am Pulverturm 3, D-6500, Mainz, Federal Republic of Germany aut Rittner Gabriele Institut für Rechtsmedizin, Kerststrasse 27-31, D-6750, Kaiserslautern, Federal Republic of Germany aut Brissot Pierre Clinique de Medicine Interne et des Maladies du Foie, Bloc Hôpital Pontchaillou, Rue Herri Le Guilloux, F-35033, Rennes, France aut Jouanolle Herve Clinique de Medicine Interne et des Maladies du Foie, Bloc Hôpital Pontchaillou, Rue Herri Le Guilloux, F-35033, Rennes, France aut Manns Michael I. Medizinische Klinik und Poliklinik, Universitätsklinik, D-6500, Mainz, Federal Republic of Germany aut Schleiermacher Engelhardt Institut für Anthropologie der Universität, Saarstrasse 21, D-6500, Mainz, Federal Republic of Germany aut Rittner Christian Institut für Rechtsmedizin der Universität, Am Pulverturm 3, D-6500, Mainz, Federal Republic of Germany aut Human Genetics Springer-Verlag 85/5(1990-10-01), 546-550 0340-6717 85:5<546 1990 85 439 https://doi.org/10.1007/BF00194235 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00194235 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Notghi Arman Institut für Rechtsmedizin der Universität, Am Pulverturm 3, D-6500, Mainz, Federal Republic of Germany aut NATIONALLICENCE 700 1- Nestle Ursula Institut für Rechtsmedizin der Universität, Am Pulverturm 3, D-6500, Mainz, Federal Republic of Germany aut NATIONALLICENCE 700 1- Rittner Gabriele Institut für Rechtsmedizin, Kerststrasse 27-31, D-6750, Kaiserslautern, Federal Republic of Germany aut NATIONALLICENCE 700 1- Brissot Pierre Clinique de Medicine Interne et des Maladies du Foie, Bloc Hôpital Pontchaillou, Rue Herri Le Guilloux, F-35033, Rennes, France aut NATIONALLICENCE 700 1- Jouanolle Herve Clinique de Medicine Interne et des Maladies du Foie, Bloc Hôpital Pontchaillou, Rue Herri Le Guilloux, F-35033, Rennes, France aut NATIONALLICENCE 700 1- Manns Michael I. Medizinische Klinik und Poliklinik, Universitätsklinik, D-6500, Mainz, Federal Republic of Germany aut NATIONALLICENCE 700 1- Schleiermacher Engelhardt Institut für Anthropologie der Universität, Saarstrasse 21, D-6500, Mainz, Federal Republic of Germany aut NATIONALLICENCE 700 1- Rittner Christian Institut für Rechtsmedizin der Universität, Am Pulverturm 3, D-6500, Mainz, Federal Republic of Germany aut NATIONALLICENCE 773 0- Human Genetics Springer-Verlag 85/5(1990-10-01), 546-550 0340-6717 85:5<546 1990 85 439 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer