caa a22 4500 46798591X CHVBK 20180323112531.0 cr unu---uuuuu 170328e19901001xx s 000 0 eng 10.1007/BF00194229 doi (NATIONALLICENCE)springer-10.1007/BF00194229 The origin of sickle cell alleles in Israel [Elektronische Daten] [Deborah Rund, Naomi Kornhendler, Oded Shalev, Ariella Oppenheim] Summary: Molecular genetic studies were undertaken to determine the source of chromosomes carrying the sickle cell allele in Israeli patients. Analysis of restriction fragment length polymorphism (RFLP) patterns (haplotypes) along the β-globin gene cluster was performed on 31 sickle chromosomes obtained from 10 unrelated families living in Israel. One is a Caucasian Jewish family, recently found to be carrying the sickle allele, and the other 9 are Arab families of various communities. The Jewish family, previously noted not to carry African red blood cell markers, was discovered to have the most common African haplotype of the β-globin gene cluster, Benin. Similarly, 8 of the Arab families were also found to carry the Benin haplotype, whereas the ninth has the CAR (Central African Republic or Bantu) haplotype. The results suggest that sickle alleles in Israel originated in Africa, probably in two different regions, and migrated north into Arab and Jewish populations. Springer-Verlag, 1990 Rund Deborah Department of Hematology, Mt. Scopus, Hadassah University Hospital, 91120, Jerusalem, Israel aut Kornhendler Naomi Department of Hematology, Mt. Scopus, Hadassah University Hospital, 91120, Jerusalem, Israel aut Shalev Oded Department of Medicine, Mt. Scopus, Hadassah University Hospital, 91120, Jerusalem, Israel aut Oppenheim Ariella Department of Hematology, Mt. Scopus, Hadassah University Hospital, 91120, Jerusalem, Israel aut Human Genetics Springer-Verlag 85/5(1990-10-01), 521-524 0340-6717 85:5<521 1990 85 439 https://doi.org/10.1007/BF00194229 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00194229 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Rund Deborah Department of Hematology, Mt. Scopus, Hadassah University Hospital, 91120, Jerusalem, Israel aut NATIONALLICENCE 700 1- Kornhendler Naomi Department of Hematology, Mt. Scopus, Hadassah University Hospital, 91120, Jerusalem, Israel aut NATIONALLICENCE 700 1- Shalev Oded Department of Medicine, Mt. Scopus, Hadassah University Hospital, 91120, Jerusalem, Israel aut NATIONALLICENCE 700 1- Oppenheim Ariella Department of Hematology, Mt. Scopus, Hadassah University Hospital, 91120, Jerusalem, Israel aut NATIONALLICENCE 773 0- Human Genetics Springer-Verlag 85/5(1990-10-01), 521-524 0340-6717 85:5<521 1990 85 439 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer