caa a22 4500 467985979 CHVBK 20180323112532.0 cr unu---uuuuu 170328e19900701xx s 000 0 eng 10.1007/BF00193191 doi (NATIONALLICENCE)springer-10.1007/BF00193191 Chromosomal localization of the human protamine genes, PRM1 and PRM2, to 16p13.3 by in situ hybridization [Elektronische Daten] [Franck Viguié, Lionel Domenjoud, Marie-Françoise Rousseau-Merck, Jean-Pierre Dadoune, Philippe Chevaillier] Summary: Protamines are sperm-specific proteins that replace histones in the nuclear chromatin of mature spermatozoa. A chromosomal localization of the genes coding for human protamines has been achieved by in situ hybridization. Two cDNA probes of 423 bp and 397 bp containing the entire coding sequence for human protamine 1 (HP1) and human protamine 2 (HP2), respectively, have been used. The genes, called PRM1 and PRM2, have been found, tightly linked, on band 16p13.3. Arguments are given for the existence of these two genes as single copies, PRM1 coding for the unique HP1 protamine and PRM2 coding for a precursor of several proteins belonging to the HP2 family. Springer-Verlag, 1990 Viguié Franck Groupe d'Etude de la Formation et de la Maturation du Gamète Mâle, Université Paris V, 45, Rue des Saints-Pères, F-75270, Paris Cedex 06, France aut Domenjoud Lionel Institut für Humangenetik der Universität, Gosslerstrasse 12d, D-3400, Göttingen, Federal Republic of Germany aut Rousseau-Merck Marie-Françoise INSERM U301, Hôpital Saint Louis, 10, Paris Cedex, France aut Dadoune Jean-Pierre Groupe d'Etude de la Formation et de la Maturation du Gamète Mâle, Université Paris V, 45, Rue des Saints-Pères, F-75270, Paris Cedex 06, France aut Chevaillier Philippe Laboratoire de Biologie Cellulaire, Université Paris-Val de Marne, F-94010, Creteil, France aut Human Genetics Springer-Verlag 85/2(1990-07-01), 171-174 0340-6717 85:2<171 1990 85 439 https://doi.org/10.1007/BF00193191 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00193191 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Viguié Franck Groupe d'Etude de la Formation et de la Maturation du Gamète Mâle, Université Paris V, 45, Rue des Saints-Pères, F-75270, Paris Cedex 06, France aut NATIONALLICENCE 700 1- Domenjoud Lionel Institut für Humangenetik der Universität, Gosslerstrasse 12d, D-3400, Göttingen, Federal Republic of Germany aut NATIONALLICENCE 700 1- Rousseau-Merck Marie-Françoise INSERM U301, Hôpital Saint Louis, 10, Paris Cedex, France aut NATIONALLICENCE 700 1- Dadoune Jean-Pierre Groupe d'Etude de la Formation et de la Maturation du Gamète Mâle, Université Paris V, 45, Rue des Saints-Pères, F-75270, Paris Cedex 06, France aut NATIONALLICENCE 700 1- Chevaillier Philippe Laboratoire de Biologie Cellulaire, Université Paris-Val de Marne, F-94010, Creteil, France aut NATIONALLICENCE 773 0- Human Genetics Springer-Verlag 85/2(1990-07-01), 171-174 0340-6717 85:2<171 1990 85 439 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer