caa a22 4500 467986029 CHVBK 20180323112532.0 cr unu---uuuuu 170328e19900701xx s 000 0 eng 10.1007/BF00193194 doi (NATIONALLICENCE)springer-10.1007/BF00193194 Heterogeneities in the distribution of (GACA)n simple repeats in the karyotypes of primates and mouse [Elektronische Daten] [Indrajit Nanda, Claudia Deubelbeiss, Martina Guttenbach, Jörg Epplen, Michael Schmid] Summary: Tandemly organized simple repetitive sequences are widespread in all eukaryotes. The organization of the simple tetrameric (GACA)n sequences at chromosomal loci has been investigated using in situ hybridization with chemically pure oligonucleotide probes. Both biotin- and digoxigenin-attached (GACA)4 probes reveal specific hybridization signals over the short arms of all acrocentric autosomes in man. In the other examined primates the NOR-bearing autosomes could be detected by in situ hybridization with (GACA)4, and a major concentration of the GACA simple repeats could be observed on the Y chromosome in the gibbon and mouse; the hybridization site in the gibbon Y chromosome coincides particularly with the silver-stainable NOR. In the past, accumulations of (GACA)n sequences were demonstrated mainly on vertebrate sex chromosomes. Therefore, the organization of GACA simple sequences is discussed in the context of their evolutionary potential accumulation and the possible linkage with the primate rDNA loci. Springer-Verlag, 1990 Nanda Indrajit Institut für Humangenetik der Universität, Koellikerstrasse 2, D-8700, Würzburg, Federal Republic of Germany aut Deubelbeiss Claudia Institut für Humangenetik der Universität, Koellikerstrasse 2, D-8700, Würzburg, Federal Republic of Germany aut Guttenbach Martina Institut für Humangenetik der Universität, Koellikerstrasse 2, D-8700, Würzburg, Federal Republic of Germany aut Epplen Jörg Max-Planck-Institut für Psychiatrie, Am Klopferspitz 18A, D-8033, Martinsried, Federal Republic of Germany aut Schmid Michael Institut für Humangenetik der Universität, Koellikerstrasse 2, D-8700, Würzburg, Federal Republic of Germany aut Human Genetics Springer-Verlag 85/2(1990-07-01), 187-194 0340-6717 85:2<187 1990 85 439 https://doi.org/10.1007/BF00193194 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00193194 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nanda Indrajit Institut für Humangenetik der Universität, Koellikerstrasse 2, D-8700, Würzburg, Federal Republic of Germany aut NATIONALLICENCE 700 1- Deubelbeiss Claudia Institut für Humangenetik der Universität, Koellikerstrasse 2, D-8700, Würzburg, Federal Republic of Germany aut NATIONALLICENCE 700 1- Guttenbach Martina Institut für Humangenetik der Universität, Koellikerstrasse 2, D-8700, Würzburg, Federal Republic of Germany aut NATIONALLICENCE 700 1- Epplen Jörg Max-Planck-Institut für Psychiatrie, Am Klopferspitz 18A, D-8033, Martinsried, Federal Republic of Germany aut NATIONALLICENCE 700 1- Schmid Michael Institut für Humangenetik der Universität, Koellikerstrasse 2, D-8700, Würzburg, Federal Republic of Germany aut NATIONALLICENCE 773 0- Human Genetics Springer-Verlag 85/2(1990-07-01), 187-194 0340-6717 85:2<187 1990 85 439 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer