caa a22 4500 467986053 CHVBK 20180323112532.0 cr unu---uuuuu 170328e19900701xx s 000 0 eng 10.1007/BF00193207 doi (NATIONALLICENCE)springer-10.1007/BF00193207 DNA polymorphism of the human complement component C7 gene in familial deficiencies [Elektronische Daten] [Eliecer Coto, Eduardo Martínez-Naves, Orlando Domínguez, Carlos López-Larrea] Summary: A C7 cDNA probe detecting a TaqI restriction fragment length polymorphism has been used to examine the segregation of the "silent allele” (C7*Q0) in two familial deficiencies. Carrier diagnosis in healthy children is possible when both parents are heterozygotes. Only one of these two families was informative. The "silent allele” is linked to different TaqI alleles in both families. This suggests that at least two different C7*Q0 alleles are present in our population. This paper gives a protocol for genetic studies of hereditary traits in which the C7 gene and other genes tightly linked to it are involved. Springer-Verlag, 1990 Coto Eliecer Servicio de Inmunología, Hospital Covadonga, E-33006, Oviedo, Spain aut Martínez-Naves Eduardo Servicio de Inmunología, Hospital Covadonga, E-33006, Oviedo, Spain aut Domínguez Orlando Servicio de Inmunología, Hospital Covadonga, E-33006, Oviedo, Spain aut López-Larrea Carlos Servicio de Inmunología, Hospital Covadonga, E-33006, Oviedo, Spain aut Human Genetics Springer-Verlag 85/2(1990-07-01), 251-252 0340-6717 85:2<251 1990 85 439 https://doi.org/10.1007/BF00193207 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00193207 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Coto Eliecer Servicio de Inmunología, Hospital Covadonga, E-33006, Oviedo, Spain aut NATIONALLICENCE 700 1- Martínez-Naves Eduardo Servicio de Inmunología, Hospital Covadonga, E-33006, Oviedo, Spain aut NATIONALLICENCE 700 1- Domínguez Orlando Servicio de Inmunología, Hospital Covadonga, E-33006, Oviedo, Spain aut NATIONALLICENCE 700 1- López-Larrea Carlos Servicio de Inmunología, Hospital Covadonga, E-33006, Oviedo, Spain aut NATIONALLICENCE 773 0- Human Genetics Springer-Verlag 85/2(1990-07-01), 251-252 0340-6717 85:2<251 1990 85 439 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer