caa a22 4500 467986096 CHVBK 20180323112532.0 cr unu---uuuuu 170328e19900701xx s 000 0 eng 10.1007/BF00193205 doi (NATIONALLICENCE)springer-10.1007/BF00193205 Haas Oskar Forschungsinstitut für krebskranke Kinder, St. Anna Kinderspital, Kinderspitalgasse 6, A-1090, Wien, Austria aut Centromeric heterochromatin instability of chromosomes 1, 9, and 16 in variable immunodeficiency syndrome — a virus-induced phenomenon? [Elektronische Daten] [Oskar Haas] Summary: Centromeric instability of chromosomes 1, 9, and 16 has been described in eight patients with variable immunodeficiency. Although the pathogenetic relationship of these cytogenetic abnormalities with the clinical symptoms are unclear, it has nevertheless been proposed that they are a hallmark of this syndrome. Based on the clinical, immunological and cytogenetic data from the literature, a model is presented suggesting that the cytogenetic changes are not causatively involved in the immunodeficiency syndrome, but result from specific virus infections occurring as a consequence of the immunodeficiency in genetically predisposed individuals. Springer-Verlag, 1990 Human Genetics Springer-Verlag 85/2(1990-07-01), 244-246 0340-6717 85:2<244 1990 85 439 https://doi.org/10.1007/BF00193205 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00193205 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Haas Oskar Forschungsinstitut für krebskranke Kinder, St. Anna Kinderspital, Kinderspitalgasse 6, A-1090, Wien, Austria aut NATIONALLICENCE 773 0- Human Genetics Springer-Verlag 85/2(1990-07-01), 244-246 0340-6717 85:2<244 1990 85 439 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer