caa a22 4500 467986185 CHVBK 20180323112532.0 cr unu---uuuuu 170328e19901101xx s 000 0 eng 10.1007/BF00205175 doi (NATIONALLICENCE)springer-10.1007/BF00205175 The human VAV proto-oncogene maps to chromosome region 19p12→19p13.2 [Elektronische Daten] [Cecile Martinerie, Linda Cannizzaro, Carlo Croce, Kay Huebner, Shulamit Katzav, Mariano Barbacid] Summary: A novel human oncogene, designated VAV, has been recently characterized. This oncogene was generated by a rearrangement within the 5′ coding sequences of a normal cellular gene, the VAV proto-oncogene. The normal VAV gene is specifically expressed in hematopoietic cells regardless of their differentiation lineage. We now report that the VAV locus has been localized in the human genome at chromosome 19p12→ 19p13.2 by analysis of its segregation pattern in rodenthuman somatic cell hybrids and by chromosomal in situ hybridization. The VAV locus might be closely linked to the insulin receptor (INSR) locus, as suggested by comigration of INSR and VAV high-molecular-weight DNA fragments after pulsed-field gel electrophoresis. The VAV chromosomal assignment is of interest because chromosome region 19p13 is involved in different karyotypic abnormalities in a variety of malignancies including melanomas and leukemias. The identification of a novel proto-oncogene that maps to that region will enable us to define whether VAV is involved in any of the translocations observed. Springer-Verlag, 1990 Martinerie Cecile Institut Curie, Centre Universitaire de Paris-Sud, F-91405, Orsay, France aut Cannizzaro Linda Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, 3420 North Broad Street, 19140, Philadelphia, PA, USA aut Croce Carlo Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, 3420 North Broad Street, 19140, Philadelphia, PA, USA aut Huebner Kay Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, 3420 North Broad Street, 19140, Philadelphia, PA, USA aut Katzav Shulamit Developmental Oncology Section, BRI-Basic Research Program, NCI-FCRF, 21701, Frederick, MA, USA aut Barbacid Mariano Developmental Oncology Section, BRI-Basic Research Program, NCI-FCRF, 21701, Frederick, MA, USA aut Human Genetics Springer-Verlag 86/1(1990-11-01), 65-68 0340-6717 86:1<65 1990 86 439 https://doi.org/10.1007/BF00205175 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00205175 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Martinerie Cecile Institut Curie, Centre Universitaire de Paris-Sud, F-91405, Orsay, France aut NATIONALLICENCE 700 1- Cannizzaro Linda Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, 3420 North Broad Street, 19140, Philadelphia, PA, USA aut NATIONALLICENCE 700 1- Croce Carlo Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, 3420 North Broad Street, 19140, Philadelphia, PA, USA aut NATIONALLICENCE 700 1- Huebner Kay Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, 3420 North Broad Street, 19140, Philadelphia, PA, USA aut NATIONALLICENCE 700 1- Katzav Shulamit Developmental Oncology Section, BRI-Basic Research Program, NCI-FCRF, 21701, Frederick, MA, USA aut NATIONALLICENCE 700 1- Barbacid Mariano Developmental Oncology Section, BRI-Basic Research Program, NCI-FCRF, 21701, Frederick, MA, USA aut NATIONALLICENCE 773 0- Human Genetics Springer-Verlag 86/1(1990-11-01), 65-68 0340-6717 86:1<65 1990 86 439 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer