caa a22 4500 467986282 CHVBK 20180323112532.0 cr unu---uuuuu 170328e19901101xx s 000 0 eng 10.1007/BF00205183 doi (NATIONALLICENCE)springer-10.1007/BF00205183 Detection by denaturing gradient gel electrophoresis of a new polymorphism in the apolipoprotein B gene [Elektronische Daten] [Maria Navajas, Anne-Marie Laurent, Jean-François Moreel, Ashraf Ragab, Jean-Pierre Cambou, Gérard Cuny, François Cambien, Gérard Roizès] Summary: The apolipoprotein B gene is subject to mutations that may be important in coronary heart diseases. We have used polymerase chain reaction and denaturin gradient gel electrophoresis to characterize a single nucleotide substitution in the apolipoprotein B gene. This mutation affects amino acid 4311 of the protein and converts asparagine to serine. It was found in 24% of the 81 unrelated individuals analyzed. Moreover, another mutation was detected by sequencing in a single individual. Springer-Verlag, 1990 Navajas Maria CNRS UPR 8402 and INSERM U.249, Institut de Biologie, Boulevard Henri IV, F-34060, Montpellier Cedex, France aut Laurent Anne-Marie CNRS UPR 8402 and INSERM U.249, Institut de Biologie, Boulevard Henri IV, F-34060, Montpellier Cedex, France aut Moreel Jean-François INSERM U.258, INSERM SC 7, Hôpital Broussais, 96. Rue Didot, 14, Paris Cedex, France aut Ragab Ashraf INSERM U, 101, CHU Purpan, Place Baylac, F-31059, Toulouse Cedex, France aut Cambou Jean-Pierre INSERM U, 101, CHU Purpan, Place Baylac, F-31059, Toulouse Cedex, France aut Cuny Gérard CNRS UPR 8402 and INSERM U.249, Institut de Biologie, Boulevard Henri IV, F-34060, Montpellier Cedex, France aut Cambien François INSERM U.258, INSERM SC 7, Hôpital Broussais, 96. Rue Didot, 14, Paris Cedex, France aut Roizès Gérard CNRS UPR 8402 and INSERM U.249, Institut de Biologie, Boulevard Henri IV, F-34060, Montpellier Cedex, France aut Human Genetics Springer-Verlag 86/1(1990-11-01), 91-93 0340-6717 86:1<91 1990 86 439 https://doi.org/10.1007/BF00205183 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00205183 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Navajas Maria CNRS UPR 8402 and INSERM U.249, Institut de Biologie, Boulevard Henri IV, F-34060, Montpellier Cedex, France aut NATIONALLICENCE 700 1- Laurent Anne-Marie CNRS UPR 8402 and INSERM U.249, Institut de Biologie, Boulevard Henri IV, F-34060, Montpellier Cedex, France aut NATIONALLICENCE 700 1- Moreel Jean-François INSERM U.258, INSERM SC 7, Hôpital Broussais, 96. Rue Didot, 14, Paris Cedex, France aut NATIONALLICENCE 700 1- Ragab Ashraf INSERM U, 101, CHU Purpan, Place Baylac, F-31059, Toulouse Cedex, France aut NATIONALLICENCE 700 1- Cambou Jean-Pierre INSERM U, 101, CHU Purpan, Place Baylac, F-31059, Toulouse Cedex, France aut NATIONALLICENCE 700 1- Cuny Gérard CNRS UPR 8402 and INSERM U.249, Institut de Biologie, Boulevard Henri IV, F-34060, Montpellier Cedex, France aut NATIONALLICENCE 700 1- Cambien François INSERM U.258, INSERM SC 7, Hôpital Broussais, 96. Rue Didot, 14, Paris Cedex, France aut NATIONALLICENCE 700 1- Roizès Gérard CNRS UPR 8402 and INSERM U.249, Institut de Biologie, Boulevard Henri IV, F-34060, Montpellier Cedex, France aut NATIONALLICENCE 773 0- Human Genetics Springer-Verlag 86/1(1990-11-01), 91-93 0340-6717 86:1<91 1990 86 439 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer