caa a22 4500 467986355 CHVBK 20180323112533.0 cr unu---uuuuu 170328e19901101xx s 000 0 eng 10.1007/BF00205169 doi (NATIONALLICENCE)springer-10.1007/BF00205169 Ha- ras -1 alleles in Norwegian lung cancer patients [Elektronische Daten] [David Ryberg, Toril Tefre, Steinar Øvrebø, Vidar Skaug, Lodve Stangeland, Anne Naalsund, Rita Bæra, Anne-Lise Børresen, Aage Haugen] Summary: We have examined DNA restriction fragment length polymorphisms (RFLP) of the Ha-ras-1 gene in DNA from 118 lung cancer patients and 123 unaffected controls. When DNA samples were digested with MspI/ HpaII restriction endonucleases. Southern blot analysis demonstrated 4 common, 4 intermediate and 7 different rare alleles in the combined population after hybridization to the pGDa1 probe. Six of the rare alleles were unique for the lung cancer group and 1 rare allele for the control group. The frequency of rare alleles in lung cancer patients (10/236) was significantly different (P<0.01) from the control group (1/246). The lung cancer group also had a significantly lower frequency of the common 2.57 kb fragment than the controls (P<0.02). The results thus indicate that Ha-ras genotyping may be of value in lung cancer risk assessment. Springer-Verlag, 1990 Ryberg David Department of Toxicology, National Institute of Occupational Health, P.O.Box 8149, Dep. N-0033, Oslo 1, Norway aut Tefre Toril The Norwegian Radium Hospital, Montebello, Department of Genetics, N-0310, Oslo 3, Norway aut Øvrebø Steinar Department of Toxicology, National Institute of Occupational Health, P.O.Box 8149, Dep. N-0033, Oslo 1, Norway aut Skaug Vidar Department of Toxicology, National Institute of Occupational Health, P.O.Box 8149, Dep. N-0033, Oslo 1, Norway aut Stangeland Lodve Haukeland Hospital, N-5021, Bergen, Norway aut Naalsund Anne The National Hospital, N-0027, Oslo 1, Norway aut Bæra Rita Department of Toxicology, National Institute of Occupational Health, P.O.Box 8149, Dep. N-0033, Oslo 1, Norway aut Børresen Anne-Lise The Norwegian Radium Hospital, Montebello, Department of Genetics, N-0310, Oslo 3, Norway aut Haugen Aage Department of Toxicology, National Institute of Occupational Health, P.O.Box 8149, Dep. N-0033, Oslo 1, Norway aut Human Genetics Springer-Verlag 86/1(1990-11-01), 40-44 0340-6717 86:1<40 1990 86 439 https://doi.org/10.1007/BF00205169 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00205169 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ryberg David Department of Toxicology, National Institute of Occupational Health, P.O.Box 8149, Dep. N-0033, Oslo 1, Norway aut NATIONALLICENCE 700 1- Tefre Toril The Norwegian Radium Hospital, Montebello, Department of Genetics, N-0310, Oslo 3, Norway aut NATIONALLICENCE 700 1- Øvrebø Steinar Department of Toxicology, National Institute of Occupational Health, P.O.Box 8149, Dep. N-0033, Oslo 1, Norway aut NATIONALLICENCE 700 1- Skaug Vidar Department of Toxicology, National Institute of Occupational Health, P.O.Box 8149, Dep. N-0033, Oslo 1, Norway aut NATIONALLICENCE 700 1- Stangeland Lodve Haukeland Hospital, N-5021, Bergen, Norway aut NATIONALLICENCE 700 1- Naalsund Anne The National Hospital, N-0027, Oslo 1, Norway aut NATIONALLICENCE 700 1- Bæra Rita Department of Toxicology, National Institute of Occupational Health, P.O.Box 8149, Dep. N-0033, Oslo 1, Norway aut NATIONALLICENCE 700 1- Børresen Anne-Lise The Norwegian Radium Hospital, Montebello, Department of Genetics, N-0310, Oslo 3, Norway aut NATIONALLICENCE 700 1- Haugen Aage Department of Toxicology, National Institute of Occupational Health, P.O.Box 8149, Dep. N-0033, Oslo 1, Norway aut NATIONALLICENCE 773 0- Human Genetics Springer-Verlag 86/1(1990-11-01), 40-44 0340-6717 86:1<40 1990 86 439 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer