caa a22 4500 467986363 CHVBK 20180323112533.0 cr unu---uuuuu 170328e19901101xx s 000 0 eng 10.1007/BF00205168 doi (NATIONALLICENCE)springer-10.1007/BF00205168 Cytogenetic analysis of 400 sperm from three translocation heterozygotes [Elektronische Daten] [Renee Martin, Leona Barclay, Kathy Hildebrand, Evelyn Ko, S. Fowlow] Summary: Sperm chromosome complements were studied in three men who carried reciprocal translocations. A total of 400 sperm were karyotyped after in vitro penetration of hamster eggs: 217 sperm from t(2;9) (q21;p22), 164 from t(4;6) (q28;p23) and 19 from t(7;14) (q21;q13). All possible 2∶2 and 3∶1 meiotic segregations were observed for t(2;9) and t(4;6); for t(7;14) only 2∶2 segregations were observed. For alternate segregations, the number of normal sperm was not significantly different from the number of sperm carrying a balanced form of the translocation in any of the translocations, as theoretically expected. The percentage of sperm with an unbalanced form of the translocation was 57% for t(2;9), 54% for t(4;6) and 47% for t(7;14). There was no evidence for an interchromosomal effect in any of the translocations since the frequencies of numerical abnormalities (unrelated to the translocation) were within the normal range of control donors. The frequencies of X- and Y-bearing sperm did not differ significantly from 50%. Results from a total of 17 reciprocal translocations studied by sperm chromosomal analysis were reviewed. Springer-Verlag, 1990 Martin Renee Division of Medical Genetics, Department of Pediatrics, Faculty of Medicine, University of Calgary, T2T5C7, Calgary, Alberta, Canada aut Barclay Leona Medical Genetics Clinic, Alberta Children's Hospital, 1820 Richmond Road, S.W., T2T 5C7, Calgary, Alberta, Canada aut Hildebrand Kathy Medical Genetics Clinic, Alberta Children's Hospital, 1820 Richmond Road, S.W., T2T 5C7, Calgary, Alberta, Canada aut Ko Evelyn Medical Genetics Clinic, Alberta Children's Hospital, 1820 Richmond Road, S.W., T2T 5C7, Calgary, Alberta, Canada aut Fowlow S. Medical Genetics Clinic, Alberta Children's Hospital, 1820 Richmond Road, S.W., T2T 5C7, Calgary, Alberta, Canada aut Human Genetics Springer-Verlag 86/1(1990-11-01), 33-39 0340-6717 86:1<33 1990 86 439 https://doi.org/10.1007/BF00205168 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00205168 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Martin Renee Division of Medical Genetics, Department of Pediatrics, Faculty of Medicine, University of Calgary, T2T5C7, Calgary, Alberta, Canada aut NATIONALLICENCE 700 1- Barclay Leona Medical Genetics Clinic, Alberta Children's Hospital, 1820 Richmond Road, S.W., T2T 5C7, Calgary, Alberta, Canada aut NATIONALLICENCE 700 1- Hildebrand Kathy Medical Genetics Clinic, Alberta Children's Hospital, 1820 Richmond Road, S.W., T2T 5C7, Calgary, Alberta, Canada aut NATIONALLICENCE 700 1- Ko Evelyn Medical Genetics Clinic, Alberta Children's Hospital, 1820 Richmond Road, S.W., T2T 5C7, Calgary, Alberta, Canada aut NATIONALLICENCE 700 1- Fowlow S. Medical Genetics Clinic, Alberta Children's Hospital, 1820 Richmond Road, S.W., T2T 5C7, Calgary, Alberta, Canada aut NATIONALLICENCE 773 0- Human Genetics Springer-Verlag 86/1(1990-11-01), 33-39 0340-6717 86:1<33 1990 86 439 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer