caa a22 4500 467986452 CHVBK 20180323112533.0 cr unu---uuuuu 170328e19901201xx s 000 0 eng 10.1007/BF00197705 doi (NATIONALLICENCE)springer-10.1007/BF00197705 Changing paternal age distribution and the human mutation rate in Europe [Elektronische Daten] [Bernadette Modell, Anver Kuliev] Summary: All available evidence indicates that the human mutation rate increases with paternal age. In developed countries, a reduction in the proportion of older parents is a common feature of the marked changes in parental age distribution that occur as a result of family planning. We have related the current paternal age distribution in the European countries for which data is readily available, to a derived curve for paternal agespecific relative mutation rate. The results indicate that, to the extent that it is dependent on paternal age, the mutation rate has decreased considerably in developed countries during the past 50 years. The human mutation rate is a dynamic entity, continuously changing in response to social conditions. Springer-Verlag, 1990 Modell Bernadette WHO Collaborating Centre, University College and Middlesex School of Medicine, UK aut Kuliev Anver WHO Collaborating Centre, National Medical Genetics Research Centre of the Academy of Medical Sciences of the USSR, Moscow, USSR aut Human Genetics Springer-Verlag 86/2(1990-12-01), 198-202 0340-6717 86:2<198 1990 86 439 https://doi.org/10.1007/BF00197705 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00197705 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Modell Bernadette WHO Collaborating Centre, University College and Middlesex School of Medicine, UK aut NATIONALLICENCE 700 1- Kuliev Anver WHO Collaborating Centre, National Medical Genetics Research Centre of the Academy of Medical Sciences of the USSR, Moscow, USSR aut NATIONALLICENCE 773 0- Human Genetics Springer-Verlag 86/2(1990-12-01), 198-202 0340-6717 86:2<198 1990 86 439 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer