caa a22 4500 467986592 CHVBK 20180323112533.0 cr unu---uuuuu 170328e19901201xx s 000 0 eng 10.1007/BF00197711 doi (NATIONALLICENCE)springer-10.1007/BF00197711 Abnormal hemoglobins in the Silk Road region of China [Elektronische Daten] [Hou-jun Li, Xian-ning Zhao, Fan Qin, Hui-wu Li, Li Li, Xiao-jun He, Xiao-su Chang, Zhe-meng Li, Ke-xing Liang, Fa-li Xing, Wen-sun Chang, Ru-zhau Wong, Iu-li Yang, Fen-sheng Li, Tuen-tian Zhang, Ri-jun Tian, Brooke Webber, Jerry Wilson, Titus Huisman] Summary: A review is presented of the occurrence of 24 abnormal hemoglobins (13 α-chain variants and 11 β-chain variants) in populations in the Silk Road area of Northwestern China. Most frequently occurring were Hb D-Punjab [β21(GH4)Glu→Gln] in Uygurs, Kazaks, and Khalkhas, Hb G-Taipei [β22(B4)Glu→Gly] in persons of the Han nationality, and Hb G-Coushatta [β22 (B4)Glu→Ala] in the Uygurs, Kazaks, Hans, and related nationalities. The data suggest that these variants likely originated in Central Asia, in the Han nationality of China, and in the minorities of northern China, respectively. Other variants occurred at considerably lower frequencies and were imported from other countries or arose as independent mutations. Two variants [Hb Tashikuergan or α19(AB1)Ala→Glu; Hb Tianshui or β39(C5) Gln→Arg] were observed for the first time. The data from this study of the many variants support the movements of various populations in this area, as reported in numerous historical documents. Springer-Verlag, 1990 Li Hou-jun Laboratory of Medical Genetics, Western Region Hospital, Urumqi, People's Republic of China aut Zhao Xian-ning Hemoglobin Cooperative Study Group of the Lanzhou Military Area, Urumqi, People's Republic of China aut Qin Fan Laboratory of Medical Genetics, Western Region Hospital, Urumqi, People's Republic of China aut Li Hui-wu Laboratory of Medical Genetics, Western Region Hospital, Urumqi, People's Republic of China aut Li Li Laboratory of Medical Genetics, Western Region Hospital, Urumqi, People's Republic of China aut He Xiao-jun Laboratory of Medical Genetics, Western Region Hospital, Urumqi, People's Republic of China aut Chang Xiao-su Laboratory of Medical Genetics, Western Region Hospital, Urumqi, People's Republic of China aut Li Zhe-meng Hemoglobin Cooperative Study Group of the Lanzhou Military Area, Urumqi, People's Republic of China aut Liang Ke-xing Hemoglobin Cooperative Study Group of the Lanzhou Military Area, Urumqi, People's Republic of China aut Xing Fa-li Hemoglobin Cooperative Study Group of the Lanzhou Military Area, Urumqi, People's Republic of China aut Chang Wen-sun Hemoglobin Cooperative Study Group of the Lanzhou Military Area, Urumqi, People's Republic of China aut Wong Ru-zhau Hemoglobin Cooperative Study Group of the Lanzhou Military Area, Urumqi, People's Republic of China aut Yang Iu-li Hemoglobin Cooperative Study Group of the Lanzhou Military Area, Urumqi, People's Republic of China aut Li Fen-sheng Hemoglobin Cooperative Study Group of the Lanzhou Military Area, Urumqi, People's Republic of China aut Zhang Tuen-tian Hemoglobin Cooperative Study Group of the Lanzhou Military Area, Urumqi, People's Republic of China aut Tian Ri-jun Hemoglobin Cooperative Study Group of the Lanzhou Military Area, Urumqi, People's Republic of China aut Webber Brooke Laboratory of Protein Chemistry, Department of Cell and Molecular Biology, Medical College of Georgia, 30912-2100, Augusta, GA, USA aut Wilson Jerry Laboratory of Protein Chemistry, Department of Cell and Molecular Biology, Medical College of Georgia, 30912-2100, Augusta, GA, USA aut Huisman Titus Laboratory of Protein Chemistry, Department of Cell and Molecular Biology, Medical College of Georgia, 30912-2100, Augusta, GA, USA aut Human Genetics Springer-Verlag 86/2(1990-12-01), 231-235 0340-6717 86:2<231 1990 86 439 https://doi.org/10.1007/BF00197711 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00197711 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Li Hou-jun Laboratory of Medical Genetics, Western Region Hospital, Urumqi, People's Republic of China aut NATIONALLICENCE 700 1- Zhao Xian-ning Hemoglobin Cooperative Study Group of the Lanzhou Military Area, Urumqi, People's Republic of China aut NATIONALLICENCE 700 1- Qin Fan Laboratory of Medical Genetics, Western Region Hospital, Urumqi, People's Republic of China aut NATIONALLICENCE 700 1- Li Hui-wu Laboratory of Medical Genetics, Western Region Hospital, Urumqi, People's Republic of China aut NATIONALLICENCE 700 1- Li Li Laboratory of Medical Genetics, Western Region Hospital, Urumqi, People's Republic of China aut NATIONALLICENCE 700 1- He Xiao-jun Laboratory of Medical Genetics, Western Region Hospital, Urumqi, People's Republic of China aut NATIONALLICENCE 700 1- Chang Xiao-su Laboratory of Medical Genetics, Western Region Hospital, Urumqi, People's Republic of China aut NATIONALLICENCE 700 1- Li Zhe-meng Hemoglobin Cooperative Study Group of the Lanzhou Military Area, Urumqi, People's Republic of China aut NATIONALLICENCE 700 1- Liang Ke-xing Hemoglobin Cooperative Study Group of the Lanzhou Military Area, Urumqi, People's Republic of China aut NATIONALLICENCE 700 1- Xing Fa-li Hemoglobin Cooperative Study Group of the Lanzhou Military Area, Urumqi, People's Republic of China aut NATIONALLICENCE 700 1- Chang Wen-sun Hemoglobin Cooperative Study Group of the Lanzhou Military Area, Urumqi, People's Republic of China aut NATIONALLICENCE 700 1- Wong Ru-zhau Hemoglobin Cooperative Study Group of the Lanzhou Military Area, Urumqi, People's Republic of China aut NATIONALLICENCE 700 1- Yang Iu-li Hemoglobin Cooperative Study Group of the Lanzhou Military Area, Urumqi, People's Republic of China aut NATIONALLICENCE 700 1- Li Fen-sheng Hemoglobin Cooperative Study Group of the Lanzhou Military Area, Urumqi, People's Republic of China aut NATIONALLICENCE 700 1- Zhang Tuen-tian Hemoglobin Cooperative Study Group of the Lanzhou Military Area, Urumqi, People's Republic of China aut NATIONALLICENCE 700 1- Tian Ri-jun Hemoglobin Cooperative Study Group of the Lanzhou Military Area, Urumqi, People's Republic of China aut NATIONALLICENCE 700 1- Webber Brooke Laboratory of Protein Chemistry, Department of Cell and Molecular Biology, Medical College of Georgia, 30912-2100, Augusta, GA, USA aut NATIONALLICENCE 700 1- Wilson Jerry Laboratory of Protein Chemistry, Department of Cell and Molecular Biology, Medical College of Georgia, 30912-2100, Augusta, GA, USA aut NATIONALLICENCE 700 1- Huisman Titus Laboratory of Protein Chemistry, Department of Cell and Molecular Biology, Medical College of Georgia, 30912-2100, Augusta, GA, USA aut NATIONALLICENCE 773 0- Human Genetics Springer-Verlag 86/2(1990-12-01), 231-235 0340-6717 86:2<231 1990 86 439 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer