caa a22 4500 467993270 CHVBK 20180323112550.0 cr unu---uuuuu 170328e19900501xx s 000 0 eng 10.1007/BF00487431 doi (NATIONALLICENCE)springer-10.1007/BF00487431 Lactam and acid amide acetals 57. Synthesis, protonation, and acid-base properties of condensed derivatives of 4-oxo-1,4-dihydro-1,8-naphthyridine [Elektronische Daten] [L. Guss, L. Khabarova, L. Ershov, G. Dvoryantseva, N. Proshina, V. Granik] A number of 4-oxo-1,4-dihydro-1,8-naphthyridine derivatives that differ with respect to the sizes of the azaand carbocycles were synthesized by the reaction of 3-amino-4-ethoxycarbonyl-5,6-dihydro-7H-pyrindine and 3-amino-4-ethoxycarbonyl-5,6,7,8-tetrahydroisoquinoline with N,N-dimethylacetamide diethylacetal and N-methylbutyrolactam, N-methylvalerolactam, and N-methylcaprolactam diethylacetals and subsequent cyclization of the intermediate amidines. It was established by UV and 1H and 13C NMR spectroscopy that the protonation of these compounds takes place at the exocyclic oxygen atom. The dependence of the ionization constants of the compounds obtained in 70% DMFA on the size of the saturated cyclic fragments of the molecules was established. Plenum Publishing Corporation, 1990 Guss L. S. Ordzhonikidze All-Union Scientific-Research Institute of Pharmaceutical Chemistry, 119021, Moscow aut Khabarova L. S. Ordzhonikidze All-Union Scientific-Research Institute of Pharmaceutical Chemistry, 119021, Moscow aut Ershov L. S. Ordzhonikidze All-Union Scientific-Research Institute of Pharmaceutical Chemistry, 119021, Moscow aut Dvoryantseva G. S. Ordzhonikidze All-Union Scientific-Research Institute of Pharmaceutical Chemistry, 119021, Moscow aut Proshina N. S. Ordzhonikidze All-Union Scientific-Research Institute of Pharmaceutical Chemistry, 119021, Moscow aut Granik V. S. Ordzhonikidze All-Union Scientific-Research Institute of Pharmaceutical Chemistry, 119021, Moscow aut Chemistry of Heterocyclic Compounds Kluwer Academic Publishers-Plenum Publishers 26/5(1990-05-01), 544-551 0009-3122 26:5<544 1990 26 10593 https://doi.org/10.1007/BF00487431 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00487431 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Guss L. S. Ordzhonikidze All-Union Scientific-Research Institute of Pharmaceutical Chemistry, 119021, Moscow aut NATIONALLICENCE 700 1- Khabarova L. S. Ordzhonikidze All-Union Scientific-Research Institute of Pharmaceutical Chemistry, 119021, Moscow aut NATIONALLICENCE 700 1- Ershov L. S. Ordzhonikidze All-Union Scientific-Research Institute of Pharmaceutical Chemistry, 119021, Moscow aut NATIONALLICENCE 700 1- Dvoryantseva G. S. Ordzhonikidze All-Union Scientific-Research Institute of Pharmaceutical Chemistry, 119021, Moscow aut NATIONALLICENCE 700 1- Proshina N. S. Ordzhonikidze All-Union Scientific-Research Institute of Pharmaceutical Chemistry, 119021, Moscow aut NATIONALLICENCE 700 1- Granik V. S. Ordzhonikidze All-Union Scientific-Research Institute of Pharmaceutical Chemistry, 119021, Moscow aut NATIONALLICENCE 773 0- Chemistry of Heterocyclic Compounds Kluwer Academic Publishers-Plenum Publishers 26/5(1990-05-01), 544-551 0009-3122 26:5<544 1990 26 10593 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer