caa a22 4500 467995443 CHVBK 20180323112556.0 cr unu---uuuuu 170328e19900701xx s 000 0 eng 10.1007/BF01244771 doi (NATIONALLICENCE)springer-10.1007/BF01244771 Spectrophotometric determination of amikacin, kanamycin, neomycin and tobramycin [Elektronische Daten] [Maya Confino, Panayot Bontchev] A spectrophotometric method for determination of neomycin, kanamycin, tobramycin and amikacin is proposed, based on the Rimini test with disodium pentacyanonitrosylferrate(II) for primary and secondary aliphatic amines. The absorbance of the coloured addition product is measured. Beer's law is valid over a wide concentration range. The method is relatively fast and can be used in control of the manufacture of the antibiotics and their purity, instead of the much slower microbiological method. It is also applicable for determination of these antibiotics in formulations. Springer-Verlag, 1990 aminoglycoside antibiotics nationallicence spectrophotometry nationallicence disodium pentacy-anonitrosylferrate(II) nationallicence Confino Maya Analytical Department, Chemical Pharmaceutical Research Institute, 3 Kl. Ohridsky, 1197, Sofia, Bulgaria aut Bontchev Panayot Faculty of Chemistry, University of Sofia, 1 Anton Ivanov, 1126, Sofia, Bulgaria aut Microchimica Acta Springer-Verlag 102/4-6(1990-07-01), 305-309 0026-3672 102:4-6<305 1990 102 604 https://doi.org/10.1007/BF01244771 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01244771 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Confino Maya Analytical Department, Chemical Pharmaceutical Research Institute, 3 Kl. Ohridsky, 1197, Sofia, Bulgaria aut NATIONALLICENCE 700 1- Bontchev Panayot Faculty of Chemistry, University of Sofia, 1 Anton Ivanov, 1126, Sofia, Bulgaria aut NATIONALLICENCE 773 0- Microchimica Acta Springer-Verlag 102/4-6(1990-07-01), 305-309 0026-3672 102:4-6<305 1990 102 604 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer