caa a22 4500 46799630X CHVBK 20180323112558.0 cr unu---uuuuu 170328e19900101xx s 000 0 eng 10.1007/BF01244497 doi (NATIONALLICENCE)springer-10.1007/BF01244497 Spectrophotometric determination of furosemide as its Fe(III) complex in pharmaceutical preparations [Elektronische Daten] [Ljiljana Živanović, Snežana Agatonović, Dušanka Radulović] A new spectrophotometric method for determination of furosemide is described. The method is based on the reaction of furosemide with ferric chloride in pH range 5.2-6.2 and producing a red water-soluble (2 ∶ 1) complex with maximum absorbance at 513 nm. By applying the methods of Sommer and Job involving non-equimolar solutions the conditional stability constant of the complex, at the optimum pH of 5.7, and ionic strength μ=0.1M, is found to be 106.5. Beer's law is obeyed up to 8 mmol/l furosemide concentration. The detection limit of the method is 0.03 mg/ml. The relative standard deviation (n=20) is 1.03% and relative error of the method is 0.5%. The proposed method was found to be suitable for the accurate and reproducible analysis of furosemide in tablets and ampoules, what is pointed by high recovery values 98.78-100.6% and low values of relative standard deviations 1.68-2.08%. The results obtained show that the method is applicable to routine analysis. Springer-Verlag, 1990 furosemide-Fe(III) complex nationallicence composition and stability constant nationallicence dosage forms nationallicence spectrophotometry nationallicence Živanović Ljiljana Institute of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Belgrade, Dr. Subotića 8, YU-11000, Belgrade, Yugoslavia aut Agatonović Snežana Institute of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Belgrade, Dr. Subotića 8, YU-11000, Belgrade, Yugoslavia aut Radulović Dušanka Institute of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Belgrade, Dr. Subotića 8, YU-11000, Belgrade, Yugoslavia aut Microchimica Acta Springer-Verlag 100/1-2(1990-01-01), 49-54 0026-3672 100:1-2<49 1990 100 604 https://doi.org/10.1007/BF01244497 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01244497 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Živanović Ljiljana Institute of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Belgrade, Dr. Subotića 8, YU-11000, Belgrade, Yugoslavia aut NATIONALLICENCE 700 1- Agatonović Snežana Institute of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Belgrade, Dr. Subotića 8, YU-11000, Belgrade, Yugoslavia aut NATIONALLICENCE 700 1- Radulović Dušanka Institute of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Belgrade, Dr. Subotića 8, YU-11000, Belgrade, Yugoslavia aut NATIONALLICENCE 773 0- Microchimica Acta Springer-Verlag 100/1-2(1990-01-01), 49-54 0026-3672 100:1-2<49 1990 100 604 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer