caa a22 4500 469026057 CHVBK 20180323132730.0 cr unu---uuuuu 170328e19920201xx s 000 0 eng 10.1007/BF01989220 doi (NATIONALLICENCE)springer-10.1007/BF01989220 Detection of contamination with antineoplastic agents in a hospital pharmacy department [Elektronische Daten] [Paul Sessink, Rob Anzion, Petra Van den Broek, Rob Bos] The contamination with fluorouracil, cyclophosphamide and methotrexate was studied in a hospital pharmacy department where these drugs were prepared. In the preparation room, air samples were taken before and during preparation of the drugs. Methotrexate was detected in one sample which was collected during preparation (0.3μg/m3). Spot samples were taken in the vertical laminar airflow safety hood before and after preparation of the drugs and after cleaning of the hood. Contamination of the laminar airflow hood was: cyclophosphamide: 1-160 ng/cm2; fluorouracil: 10-62 ng/cm2 and methotrexate: 2-633 ng/cm2. Spot samples from the floor in front of and beneath the laminar airflow hood showed contamination with especially fluorouracil (48-236μg/m2). The gloves used during preparation of the drugs were contaminated mainly with fluorouracil (5-980 ng/cm2). Urine samples from two workers involved in the preparation of the drugs were analysed for unmetabolized cyclophosphamide; it was not detected. Although no uptake of cyclophosphamide was established, it is shown that the methods for measurement of cyclophosphamide, fluorouracil and methotrexate in the preparation room are applicable for the control of occupational exposure to these drugs. Royal Dutch Association for Advancement of Pharmacy, 1992 Contamination nationallicence Cyclophosphamide nationallicence Drug compounding nationallicence Fluorouracil nationallicence Methotrexate nationallicence Occupational exposure nationallicence Pharmacy service, hospital nationallicence Sessink Paul Department of Toxicology, Faculty of Medical Sciences, University of Nijmegen, P.O. Box 9101, 6500, HB Nijmegen, The Netherlands aut Anzion Rob Department of Toxicology, Faculty of Medical Sciences, University of Nijmegen, P.O. Box 9101, 6500, HB Nijmegen, The Netherlands aut Van den Broek Petra Department of Toxicology, Faculty of Medical Sciences, University of Nijmegen, P.O. Box 9101, 6500, HB Nijmegen, The Netherlands aut Bos Rob Department of Toxicology, Faculty of Medical Sciences, University of Nijmegen, P.O. Box 9101, 6500, HB Nijmegen, The Netherlands aut Pharmaceutisch Weekblad Kluwer Academic Publishers 14/1(1992-02-01), 16-22 0031-6911 14:1<16 1992 14 11096 https://doi.org/10.1007/BF01989220 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01989220 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sessink Paul Department of Toxicology, Faculty of Medical Sciences, University of Nijmegen, P.O. Box 9101, 6500, HB Nijmegen, The Netherlands aut NATIONALLICENCE 700 1- Anzion Rob Department of Toxicology, Faculty of Medical Sciences, University of Nijmegen, P.O. Box 9101, 6500, HB Nijmegen, The Netherlands aut NATIONALLICENCE 700 1- Van den Broek Petra Department of Toxicology, Faculty of Medical Sciences, University of Nijmegen, P.O. Box 9101, 6500, HB Nijmegen, The Netherlands aut NATIONALLICENCE 700 1- Bos Rob Department of Toxicology, Faculty of Medical Sciences, University of Nijmegen, P.O. Box 9101, 6500, HB Nijmegen, The Netherlands aut NATIONALLICENCE 773 0- Pharmaceutisch Weekblad Kluwer Academic Publishers 14/1(1992-02-01), 16-22 0031-6911 14:1<16 1992 14 11096 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer