caa a22 4500 469026065 CHVBK 20180323132730.0 cr unu---uuuuu 170328e19920201xx s 000 0 eng 10.1007/BF01989222 doi (NATIONALLICENCE)springer-10.1007/BF01989222 Pharmacokinetics of amoxycillin in elderly in-patients [Elektronische Daten] [R. Janknegt, J. Boogaard-Van den Born, B. Hameleers, P. Hooymans, J. Rang, C. Smits, M. Willems Thissen] The pharmacokinetics of amoxycillin (500 mg) given by intravenous injection and as two oral formulations on three consecutive days were investigated in eight frail elderly in-patients. Marked interindividual variation was found in all kinetic parameters after intravenous injection. The area under the curve (AUC) ranged from 32 to 155 mg·l−1·h and the distribution volume ranged from 13 to 37 1. The mean plasma clearance was 109 ml/min (range 53 to 255 ml/min). Elimination half-life ranged from 1.6 to 3.0 h (mean 2.4 h). The absolute bioavailability after oral administration was highly variable and ranged from 24 to 86% (mean 55%). The bioavailability of the two formulations was not significantly different. The performance of a pharmacokinetic study in these patients was very difficult, regarding their inability to tolerate an intravenous infusion, incontinence, disruption of everyday routine and problems with drinking the required volume of water. Royal Dutch Association for Advancement of Pharmacy, 1992 Amoxycillin nationallicence Biological availability nationallicence Capsules nationallicence Frail elderly nationallicence Injections, intravenous nationallicence Pharmacokinetics nationallicence Tablets nationallicence Janknegt R. Department of Clinical Pharmacy, Maasland Hospital, P.O. Box 5500, 6130, MB Sittard, The Netherlands aut Boogaard-Van den Born J. Department of Clinical Pharmacy, Maasland Hospital, P.O. Box 5500, 6130, MB Sittard, The Netherlands aut Hameleers B. Department of Clinical Pharmacy, Maasland Hospital, P.O. Box 5500, 6130, MB Sittard, The Netherlands aut Hooymans P. Department of Clinical Pharmacy, Maasland Hospital, P.O. Box 5500, 6130, MB Sittard, The Netherlands aut Rang J. Department of Clinical Pharmacy, Maasland Hospital, P.O. Box 5500, 6130, MB Sittard, The Netherlands aut Smits C. Department of Clinical Pharmacy, Maasland Hospital, P.O. Box 5500, 6130, MB Sittard, The Netherlands aut Willems Thissen M. Department of Clinical Pharmacy, Maasland Hospital, P.O. Box 5500, 6130, MB Sittard, The Netherlands aut Pharmaceutisch Weekblad Kluwer Academic Publishers 14/1(1992-02-01), 27-29 0031-6911 14:1<27 1992 14 11096 https://doi.org/10.1007/BF01989222 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01989222 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Janknegt R. Department of Clinical Pharmacy, Maasland Hospital, P.O. Box 5500, 6130, MB Sittard, The Netherlands aut NATIONALLICENCE 700 1- Boogaard-Van den Born J. Department of Clinical Pharmacy, Maasland Hospital, P.O. Box 5500, 6130, MB Sittard, The Netherlands aut NATIONALLICENCE 700 1- Hameleers B. Department of Clinical Pharmacy, Maasland Hospital, P.O. Box 5500, 6130, MB Sittard, The Netherlands aut NATIONALLICENCE 700 1- Hooymans P. Department of Clinical Pharmacy, Maasland Hospital, P.O. Box 5500, 6130, MB Sittard, The Netherlands aut NATIONALLICENCE 700 1- Rang J. Department of Clinical Pharmacy, Maasland Hospital, P.O. Box 5500, 6130, MB Sittard, The Netherlands aut NATIONALLICENCE 700 1- Smits C. Department of Clinical Pharmacy, Maasland Hospital, P.O. Box 5500, 6130, MB Sittard, The Netherlands aut NATIONALLICENCE 700 1- Willems Thissen M. Department of Clinical Pharmacy, Maasland Hospital, P.O. Box 5500, 6130, MB Sittard, The Netherlands aut NATIONALLICENCE 773 0- Pharmaceutisch Weekblad Kluwer Academic Publishers 14/1(1992-02-01), 27-29 0031-6911 14:1<27 1992 14 11096 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer