caa a22 4500 469026073 CHVBK 20180323132730.0 cr unu---uuuuu 170328e19920201xx s 000 0 eng 10.1007/BF01989221 doi (NATIONALLICENCE)springer-10.1007/BF01989221 Stability of morphine hydrochloride in a portable pump reservoir [Elektronische Daten] [P. Roos, J. Glerum, J. Meilink] The stability of morphine hydrochloride in an admixture with sodium chloride 0.9% injection in a portable pump reservoir was investigated. Duplicate samples containing morphine hydrochloride 0.5, 1.5 and 2.5 mg/ml were stored in original 100 ml plastic drug reservoirs at 32 °C for 60 days. An amount of 3 ml was removed immediately after preparation and at fixed intervals in the weeks after. All samples were tested for loss of vehicle, for appearance of precipitation and for change in colour or pH. Furthermore, they were analysed for drug concentration using high pressure liquid chromatography. No precipitation or change in colour was observed in any of the sample admixtures. There was no change in the pH values of any of the morphine hydrochloride concentrations from day 4 and later on. Only between day 1 and day 4 a slight, but not significant rise could be detected. There was no loss of morphine hydrochloride of any importance at any concentration in the samples over 60 days when corrected for loss of vehicle. Loss of vehicle (0.8±0.1 ml a week), on the other hand, gave a rise in morphine hydrochloride concentration. Royal Dutch Association for Advancement of Pharmacy, 1992 Drug stability nationallicence Infusion pumps nationallicence Morphine nationallicence Roos P. Department of Pharmacy, University Hospital Rotterdam, Dr. Molewaterplein 40, 3015, GD Rotterdam, The Netherlands aut Glerum J. Department of Pharmacy, Utrecht University, P.O. Box 80.082, 3508, TB Utrecht, The Netherlands aut Meilink J. Department of Pharmacy, University Hospital Rotterdam, Dr. Molewaterplein 40, 3015, GD Rotterdam, The Netherlands aut Pharmaceutisch Weekblad Kluwer Academic Publishers 14/1(1992-02-01), 23-26 0031-6911 14:1<23 1992 14 11096 https://doi.org/10.1007/BF01989221 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01989221 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Roos P. Department of Pharmacy, University Hospital Rotterdam, Dr. Molewaterplein 40, 3015, GD Rotterdam, The Netherlands aut NATIONALLICENCE 700 1- Glerum J. Department of Pharmacy, Utrecht University, P.O. Box 80.082, 3508, TB Utrecht, The Netherlands aut NATIONALLICENCE 700 1- Meilink J. Department of Pharmacy, University Hospital Rotterdam, Dr. Molewaterplein 40, 3015, GD Rotterdam, The Netherlands aut NATIONALLICENCE 773 0- Pharmaceutisch Weekblad Kluwer Academic Publishers 14/1(1992-02-01), 23-26 0031-6911 14:1<23 1992 14 11096 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer