caa a22 4500 46902612X CHVBK 20180323132730.0 cr unu---uuuuu 170328e19921201xx s 000 0 eng 10.1007/BF01970170 doi (NATIONALLICENCE)springer-10.1007/BF01970170 Administration of oral chloral hydrate to paediatric patients undergoing magnetic resonance imaging [Elektronische Daten] [Crisanto Ronchera, Luis Martí-Bonmatí, Cecilio Poyatos, José Vilar, N. Jiménez] Sedation is frequently required in children undergoing magnetic resonance imaging (MRI). 172 Paediatric patients (82 female and 90 male, age 42±26 months, weight 14.7±5.6 kg) entered an open, non-comparative, prospective study to assess the utilization of oral chloral hydrate. Chloral hydrate syrup (70 mg/ml) was administered 20-30 min prior to the procedure. Effective sedation was reached in 80.3% with an average initial dose of 55 mg/kg and in 93.6% with an average total dose of 65 mg/kg. Significant differences in effectivity were correlated with the dose (54±11 mg/kg in failure cases versus 66±16 mg/kg in effective cases; p <0.05) and diagnosis (effectivity falls to 62.5% and 76.0% in children with medullar tumours and encephalic white matter alterations, respectively; p <0.01). Average sleep induction time was 30±19 min, and average duration of sleep was 62±24 min. Adverse reactions occurred in 4.7%, with nausea, vomiting and stomach pain being the most common side-effects (3.5%). Multivariate statistical analysis selects total dose and age into the discriminant function, with a 100% relative percentage of correct classification. A simple method for optimizing the chloral hydrate dose in children is proposed: the dose in mg/kg is calculated as half the age in months + 50. Royal Dutch Association for Advancement of Pharmacy, 1992 Children nationallicence Chloral hydrate nationallicence Dosage nationallicence Sedation nationallicence Ronchera Crisanto Department of Pharmacy, Hospital Dr. Peset, Avenida Gaspar Aguilar 90, E-46017, Valencia, Spain aut Martí-Bonmatí Luis Department of Diagnostic Radiology, Hospital Dr. Peset, Valencia aut Poyatos Cecilio Department of Diagnostic Radiology, Hospital Dr. Peset, Valencia aut Vilar José Department of Diagnostic Radiology, Hospital Dr. Peset, Valencia aut Jiménez N. Department of Pharmacy, Hospital Dr. Peset, Avenida Gaspar Aguilar 90, E-46017, Valencia, Spain aut Pharmaceutisch Weekblad Kluwer Academic Publishers 14/6(1992-12-01), 349-352 0031-6911 14:6<349 1992 14 11096 https://doi.org/10.1007/BF01970170 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01970170 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ronchera Crisanto Department of Pharmacy, Hospital Dr. Peset, Avenida Gaspar Aguilar 90, E-46017, Valencia, Spain aut NATIONALLICENCE 700 1- Martí-Bonmatí Luis Department of Diagnostic Radiology, Hospital Dr. Peset, Valencia aut NATIONALLICENCE 700 1- Poyatos Cecilio Department of Diagnostic Radiology, Hospital Dr. Peset, Valencia aut NATIONALLICENCE 700 1- Vilar José Department of Diagnostic Radiology, Hospital Dr. Peset, Valencia aut NATIONALLICENCE 700 1- Jiménez N. Department of Pharmacy, Hospital Dr. Peset, Avenida Gaspar Aguilar 90, E-46017, Valencia, Spain aut NATIONALLICENCE 773 0- Pharmaceutisch Weekblad Kluwer Academic Publishers 14/6(1992-12-01), 349-352 0031-6911 14:6<349 1992 14 11096 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer