caa a22 4500 469026138 CHVBK 20180323132730.0 cr unu---uuuuu 170328e19921201xx s 000 0 eng 10.1007/BF01970173 doi (NATIONALLICENCE)springer-10.1007/BF01970173 High pressure liquid chromatographic analysis of the serum concentration of cefuroxime after an intravenous bolus injection of cefuroxime in patients with a coronary artery bypass grafting [Elektronische Daten] [M. Koot, F. Ijdenberg, R. Stuurman, J. Poell, L. Bras, J. Langemeijer, L. Huen] A simple reversed-phase high pressure liquid chromatographic method was developed for the determination of cefuroxime in the serum of patients undergoing coronary artery bypass grafting. The serum was cleaned up with a 3.3% solution of perchloric acid in water. Cefalexine was used as an internal standard. Detection was made by a UV multi-wavelength detector. The optimum wavelength for cefuroxime is 275 nm. The absolute recovery of this method was 90.9%; the limit of quantification was 0.7 mg/l. This analytical method was used in a study to investigate the cefuroxime serum concentration-time curves in 26 patients undergoing coronary artery bypass grafting. It was found that one single dose is sufficient to obtain effective serum concentrations. Royal Dutch Association for Advancement of Pharmacy, 1992 Cefuroxime nationallicence Chromatography, high pressure nationallicence liquid nationallicence Pharmacokinetics nationallicence Koot M. Department of Clinical Pharmacy, St. Antonius Hospital, P.O. Box 2500, 3430, EM Nieuwegein, the Netherlands aut Ijdenberg F. Department of Clinical Pharmacy, St. Antonius Hospital, P.O. Box 2500, 3430, EM Nieuwegein, the Netherlands aut Stuurman R. Department of Clinical Pharmacy, St. Antonius Hospital, P.O. Box 2500, 3430, EM Nieuwegein, the Netherlands aut Poell J. Department of Anaesthesiology, St. Antonius Hospital, the Netherlands aut Bras L. Department of Anaesthesiology, St. Antonius Hospital, the Netherlands aut Langemeijer J. Department of Anaesthesiology, St. Antonius Hospital, the Netherlands aut Huen L. Department of Clinical Pharmacy, St. Antonius Hospital, P.O. Box 2500, 3430, EM Nieuwegein, the Netherlands aut Pharmaceutisch Weekblad Kluwer Academic Publishers 14/6(1992-12-01), 360-364 0031-6911 14:6<360 1992 14 11096 https://doi.org/10.1007/BF01970173 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01970173 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Koot M. Department of Clinical Pharmacy, St. Antonius Hospital, P.O. Box 2500, 3430, EM Nieuwegein, the Netherlands aut NATIONALLICENCE 700 1- Ijdenberg F. Department of Clinical Pharmacy, St. Antonius Hospital, P.O. Box 2500, 3430, EM Nieuwegein, the Netherlands aut NATIONALLICENCE 700 1- Stuurman R. Department of Clinical Pharmacy, St. Antonius Hospital, P.O. Box 2500, 3430, EM Nieuwegein, the Netherlands aut NATIONALLICENCE 700 1- Poell J. Department of Anaesthesiology, St. Antonius Hospital, the Netherlands aut NATIONALLICENCE 700 1- Bras L. Department of Anaesthesiology, St. Antonius Hospital, the Netherlands aut NATIONALLICENCE 700 1- Langemeijer J. Department of Anaesthesiology, St. Antonius Hospital, the Netherlands aut NATIONALLICENCE 700 1- Huen L. Department of Clinical Pharmacy, St. Antonius Hospital, P.O. Box 2500, 3430, EM Nieuwegein, the Netherlands aut NATIONALLICENCE 773 0- Pharmaceutisch Weekblad Kluwer Academic Publishers 14/6(1992-12-01), 360-364 0031-6911 14:6<360 1992 14 11096 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer