caa a22 4500 469026219 CHVBK 20180323132730.0 cr unu---uuuuu 170328e19920601xx s 000 0 eng 10.1007/BF01962697 doi (NATIONALLICENCE)springer-10.1007/BF01962697 Differentiation between valproate-induced anticonvulsant effect, teratogenicity and hepatotoxicity [Elektronische Daten] Aspects of species variation, pharmacokinetics, metabolism and implications of structural specificity for the development of alternative antiepileptic agents such as Δ2-valproate [Heinz Nau, H. Siemes] Valproate is metabolized into a large number of compounds via various metabolic routes. Metabolic profiles depend on species and age. Hepatotoxicity may be correlated with abnormal metabolism, especially in young age. Teratogenicity is associated with specific structural requirements: a free carboxyl atom connected to a carbon atom which also carries a hydrogen, and two carbon chains. This provides a clue for the development of alternative antiepileptic agents. Royal Dutch Association for Advancement of Pharmacy, 1992 Hepatic diseases nationallicence Metabolites nationallicence Neural tube defects nationallicence Pharmacokinetics nationallicence Steatosis nationallicence Structure—activity relationship nationallicence Teratogens nationallicence Toxicology nationallicence Valproic acid nationallicence Nau Heinz Institute of Toxicology and Embryopharmacology, Free University Berlin, Garystrasse 5, D-1000, Berlin 33, Germany aut Siemes H. Rittberg Kinderklinik, Carstennstrasse, D-1000, Berlin 45, Germany aut Pharmaceutisch Weekblad Kluwer Academic Publishers 14/3(1992-06-01), 101-107 0031-6911 14:3<101 1992 14 11096 https://doi.org/10.1007/BF01962697 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01962697 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nau Heinz Institute of Toxicology and Embryopharmacology, Free University Berlin, Garystrasse 5, D-1000, Berlin 33, Germany aut NATIONALLICENCE 700 1- Siemes H. Rittberg Kinderklinik, Carstennstrasse, D-1000, Berlin 45, Germany aut NATIONALLICENCE 773 0- Pharmaceutisch Weekblad Kluwer Academic Publishers 14/3(1992-06-01), 101-107 0031-6911 14:3<101 1992 14 11096 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer