caa a22 4500 469026324 CHVBK 20180323132731.0 cr unu---uuuuu 170328e19920601xx s 000 0 eng 10.1007/BF01962708 doi (NATIONALLICENCE)springer-10.1007/BF01962708 Düsing R. Desitin Arzneimittel, Postfach 63 01 20, D-2000, Hamburg 63, Germany aut Single-dose tolerance and pharmacokinetics of 2- n -propyl-2( E )-pentenoate (Δ2( E )-valproate) in healthy male volunteers [Elektronische Daten] [R. Düsing] 2-n-Propyl-2(E)-pentenoic acid (Δ2(E)-valproate) was administered to healthy volunteers in oral doses of 50-800 mg. The drug was tolerated well and no significant adverse effects were observed. Pharmacokinetic parameters were determined. Valproate and 3-keto-valproate were detected as metabolites. Royal Dutch Association for Advancement of Pharmacy, 1992 Drug evaluation nationallicence Pharmacokinetics nationallicence 2- n -Propyl-2( E )-pentenoic acid nationallicence Side effects nationallicence Valproic acid nationallicence Pharmaceutisch Weekblad Kluwer Academic Publishers 14/3(1992-06-01), 152-158 0031-6911 14:3<152 1992 14 11096 https://doi.org/10.1007/BF01962708 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01962708 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Düsing R. Desitin Arzneimittel, Postfach 63 01 20, D-2000, Hamburg 63, Germany aut NATIONALLICENCE 773 0- Pharmaceutisch Weekblad Kluwer Academic Publishers 14/3(1992-06-01), 152-158 0031-6911 14:3<152 1992 14 11096 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer