caa a22 4500 469026359 CHVBK 20180323132731.0 cr unu---uuuuu 170328e19920601xx s 000 0 eng 10.1007/BF01962700 doi (NATIONALLICENCE)springer-10.1007/BF01962700 Valproate hepatotoxicity syndrome: Hypotheses of pathogenesis [Elektronische Daten] [Jeffrey Stephens, René Levy] Therapeutic use of the anticonvulsant valproate (VPA) has been associated with a rare, but severe and often fatal hepatotoxicity. Cases usually present with lethargy, anorexia, and vomiting with rapid progression to coma. Liver histopathology is characterized by steatosis with and without necrosis. In some instances only necrosis was present. Several hypotheses of pathogenesis have been postulated. These deal mainly with biochemical systems that are known to be affected by VPA, or with the possible idiosyncratic production of toxic VPA metabolites, especially Δ4-VPA. At present, no hypothesis entirely explains the diverse characteristics of the disorder. Royal Dutch Association for Advancement of Pharmacy, 1992 Biotransformation nationallicence Carnitine nationallicence Hyperammonemia nationallicence Liver disease nationallicence Metabolites nationallicence Necrosis nationallicence Pathology nationallicence Steatosis nationallicence Valproic acid nationallicence Stephens Jeffrey Department of Pharmaceutics, School of Pharmacy, BG-20, University of Washington, 98195, Seattle, Washington, USA aut Levy René Department of Pharmaceutics, School of Pharmacy, BG-20, University of Washington, 98195, Seattle, Washington, USA aut Pharmaceutisch Weekblad Kluwer Academic Publishers 14/3(1992-06-01), 118-121 0031-6911 14:3<118 1992 14 11096 https://doi.org/10.1007/BF01962700 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01962700 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Stephens Jeffrey Department of Pharmaceutics, School of Pharmacy, BG-20, University of Washington, 98195, Seattle, Washington, USA aut NATIONALLICENCE 700 1- Levy René Department of Pharmaceutics, School of Pharmacy, BG-20, University of Washington, 98195, Seattle, Washington, USA aut NATIONALLICENCE 773 0- Pharmaceutisch Weekblad Kluwer Academic Publishers 14/3(1992-06-01), 118-121 0031-6911 14:3<118 1992 14 11096 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer