caa a22 4500 469026456 CHVBK 20180323132731.0 cr unu---uuuuu 170328e19920801xx s 000 0 eng 10.1007/BF01962537 doi (NATIONALLICENCE)springer-10.1007/BF01962537 Clearance of indometacin occurs predominantly by renal glucuronidation [Elektronische Daten] [Frits Moolenaar, Sjouke Crancrinus, Jan Visser, Dick De Zeeuw, Dirk Meijer] In this report we describe the conditions of collection, storage and handling of urine samples, collected after oral dosing with indometacin in man, in order to maintain the integrity of the labile glucuronide formed. We found that the body clearance occurs predominantly by renal metabolism, due to glucuronidation in the human kidney. These glucuronides may be converted to isomeric glucuronides and/or the parent compound indometacin during the residence time in the bladder. Royal Dutch Association for Advancement of Pharmacy, 1992 Clearance, metabolic nationallicence Clearance, renal nationallicence Glucuronates nationallicence Indometacin nationallicence Pharmacokinetics nationallicence Moolenaar Frits Department of Pharmacology and Therapeutics, University Centre for Pharmacy, Ant. Deusinglaan 2, 9713, AW Groningen, the Netherlands aut Crancrinus Sjouke Pharmacy Huis te Lande, Huis te Landelaan 476a, 2283, VJ Rijswijk, the Netherlands aut Visser Jan Department of Pharmacology and Therapeutics, University Centre for Pharmacy, Ant. Deusinglaan 2, 9713, AW Groningen, the Netherlands aut De Zeeuw Dick Department of Nephrology, University Hospital Groningen, P.O. Box 30.001, 9600, RB Groningen, the Netherlands aut Meijer Dirk Department of Pharmacology and Therapeutics, University Centre for Pharmacy, Ant. Deusinglaan 2, 9713, AW Groningen, the Netherlands aut Pharmaceutisch Weekblad Kluwer Academic Publishers 14/4(1992-08-01), 191-195 0031-6911 14:4<191 1992 14 11096 https://doi.org/10.1007/BF01962537 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01962537 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Moolenaar Frits Department of Pharmacology and Therapeutics, University Centre for Pharmacy, Ant. Deusinglaan 2, 9713, AW Groningen, the Netherlands aut NATIONALLICENCE 700 1- Crancrinus Sjouke Pharmacy Huis te Lande, Huis te Landelaan 476a, 2283, VJ Rijswijk, the Netherlands aut NATIONALLICENCE 700 1- Visser Jan Department of Pharmacology and Therapeutics, University Centre for Pharmacy, Ant. Deusinglaan 2, 9713, AW Groningen, the Netherlands aut NATIONALLICENCE 700 1- De Zeeuw Dick Department of Nephrology, University Hospital Groningen, P.O. Box 30.001, 9600, RB Groningen, the Netherlands aut NATIONALLICENCE 700 1- Meijer Dirk Department of Pharmacology and Therapeutics, University Centre for Pharmacy, Ant. Deusinglaan 2, 9713, AW Groningen, the Netherlands aut NATIONALLICENCE 773 0- Pharmaceutisch Weekblad Kluwer Academic Publishers 14/4(1992-08-01), 191-195 0031-6911 14:4<191 1992 14 11096 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer