caa a22 4500 469026529 CHVBK 20180323132731.0 cr unu---uuuuu 170328e19920801xx s 000 0 eng 10.1007/BF01962532 doi (NATIONALLICENCE)springer-10.1007/BF01962532 Putative therapeutic applications of calmodulin antagonists [Elektronische Daten] [Raimund Mannhold, Hendrik Timmerman] Calmodulin is the most important intracellular receptor protein for the second messenger calcium. The calcium-calmodulin complex regulates a number of physiological processes. An increasing number of pharmaceutical products is reported to interfere with the calcium-calmodulin complex. Despite the fact that the precise mechanisms of action of these so-called calmodulin antagonists await further clarification, reports accumulate in the literature indicating a broadening spectrum of putative therapeutic applications of calmodulin antagonists. Some of these applications, such as in cell proliferation, hypertension, congestive heart failure, arrhythmia and gastro-intestinal disorders, are discussed in the present review. Royal Dutch Association for Advancement of Pharmacy, 1992 Arrhythmia nationallicence Calcium nationallicence Calmodulin/antagonists & inhibitors nationallicence Cardiomyopathy, congestive nationallicence Drug therapy nationallicence Gastrointestinal diseases nationallicence Hypertension nationallicence Neoplasms nationallicence Mannhold Raimund Molecular Drug Research Group, Biomedical Research Centre, Heinrich-Heine-Universität, D-4000, Düsseldorf 1, FRG aut Timmerman Hendrik Department of Pharmacochemistry, Free University, De Boelelaan 1083, 1081, HV Amsterdam, the Netherlands aut Pharmaceutisch Weekblad Kluwer Academic Publishers 14/4(1992-08-01), 161-166 0031-6911 14:4<161 1992 14 11096 https://doi.org/10.1007/BF01962532 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01962532 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mannhold Raimund Molecular Drug Research Group, Biomedical Research Centre, Heinrich-Heine-Universität, D-4000, Düsseldorf 1, FRG aut NATIONALLICENCE 700 1- Timmerman Hendrik Department of Pharmacochemistry, Free University, De Boelelaan 1083, 1081, HV Amsterdam, the Netherlands aut NATIONALLICENCE 773 0- Pharmaceutisch Weekblad Kluwer Academic Publishers 14/4(1992-08-01), 161-166 0031-6911 14:4<161 1992 14 11096 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer