caa a22 4500 469026537 CHVBK 20180323132731.0 cr unu---uuuuu 170328e19920801xx s 000 0 eng 10.1007/BF01962538 doi (NATIONALLICENCE)springer-10.1007/BF01962538 Stability of sufentanil citrate in a portable pump reservoir, a glass container and a polyethylene container [Elektronische Daten] [P. Roos, J. Glerum, J. Meilink] The stability of sufentanil citrate (100 ml, 5μg/ml) in an admixture with sodium chloride 0.9% injection was investigated when filled in a portable pump reservoir with PVC wall, a glass container and a polyethylene container, at 32°C, 4°C and −20°C for up to 21 days. No change in colour was visually observed in any of the samples during the 21-day storage period. A slight precipitation was noticed in three out of nine portable pump reservoirs, one at each storage temperature. There was a slight rise in pH at each storage temperature in all samples. There was approximately 13% loss of sufentanil citrate in the portable pump reservoirs stored at 32°C during 2 days and 60% loss after 21 days, due to absorption of sufentanil citrate in the reservoir wall. No loss of sufentanil citrate could be detected in the portable pump reservoirs when stored at −20°C and 4°C. However, a serious inhomogeneity of the sufentanil citrate solution occurred after thawing at room temperature in the portable pump reservoirs which had been kept at −20°C. The homogeneity could be restored by shaking for approximately 10 min. There was no change in the sufentanil citrate concentrations in the glass containers and polyethylene containers stored at the three temperatures. The portable pump reservoirs stored at 32°C also showed a significant loss of vehicle due to evaporation (1.0±0.1 ml a week). This could not be detected in any of the other samples. Royal Dutch Association for Advancement of Pharmacy, 1992 Drug stability nationallicence Glass nationallicence Infusion pumps nationallicence Polyethylene nationallicence Polyvinyl chloride nationallicence Sufentanil nationallicence Roos P. University Hospital Rotterdam-Dijkzigt, Dr. Molewaterplein 40, 3015, GD Rotterdam, the Netherlands aut Glerum J. Department of Pharmacy, University Hospital Utrecht, P.O. Box 85500, 3508, GA Utrecht, the Netherlands aut Meilink J. Department of Pharmacy, University Hospital Rotterdam-Dijkzigt, the Netherlands aut Pharmaceutisch Weekblad Kluwer Academic Publishers 14/4(1992-08-01), 196-200 0031-6911 14:4<196 1992 14 11096 https://doi.org/10.1007/BF01962538 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01962538 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Roos P. University Hospital Rotterdam-Dijkzigt, Dr. Molewaterplein 40, 3015, GD Rotterdam, the Netherlands aut NATIONALLICENCE 700 1- Glerum J. Department of Pharmacy, University Hospital Utrecht, P.O. Box 85500, 3508, GA Utrecht, the Netherlands aut NATIONALLICENCE 700 1- Meilink J. Department of Pharmacy, University Hospital Rotterdam-Dijkzigt, the Netherlands aut NATIONALLICENCE 773 0- Pharmaceutisch Weekblad Kluwer Academic Publishers 14/4(1992-08-01), 196-200 0031-6911 14:4<196 1992 14 11096 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer