caa a22 4500 469026545 CHVBK 20180323132731.0 cr unu---uuuuu 170328e19920801xx s 000 0 eng 10.1007/BF01962542 doi (NATIONALLICENCE)springer-10.1007/BF01962542 Loonen Anton Central Hospital Pharmacy 1, P.O. Box 90,153, 5200, ME 's-Hertogenbosch, the Netherlands aut Dealing with sadness, madness and hostility [Elektronische Daten] New psychotropic drug remedies for the future [Anton Loonen] The objective of this article is to present an overview of new forms of psychotropic drug therapy that may be expected to play a role in psychiatric practice in the 1990s. In predicting these future developments, three lines of approach have been followed. Firstly, progress in elucidating basic neuronal mechanisms is described. The radioligand receptor binding technique has proved to be an especially powerful tool in the search for novel psychoactive compounds. Secondly, those mental health problems most likely to undergo intensive study are discussed. It is likely that special attention will be devoted to organic mental disorders related to aging (dementia) or chronic exposure to toxic substances. In addition, research will be aimed at explaining and reducing the occurrence of auto-aggressive and hetero-aggressive behaviour. Thirdly, the types of newly designed agents and treatment strategies currently under investigation are outlined. In particular, the development of pharmacological agents that interfere with serotonergic molecular mechanisms has opened the way to improving existing psychotropic drugs, to inventing drugs that achieve known clinical effects via different mechanisms of action, and even to discovering entirely new categories of psychotropic drugs. Royal Dutch Association for Advancement of Pharmacy, 1992 Antidepressive agents nationallicence Drug design nationallicence Mental disorders nationallicence Neurosciences nationallicence Psychotropic drugs nationallicence Serenics nationallicence Tranquilizing agents nationallicence Pharmaceutisch Weekblad Kluwer Academic Publishers 14/4(1992-08-01), 206-220 0031-6911 14:4<206 1992 14 11096 https://doi.org/10.1007/BF01962542 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01962542 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Loonen Anton Central Hospital Pharmacy 1, P.O. Box 90,153, 5200, ME 's-Hertogenbosch, the Netherlands aut NATIONALLICENCE 773 0- Pharmaceutisch Weekblad Kluwer Academic Publishers 14/4(1992-08-01), 206-220 0031-6911 14:4<206 1992 14 11096 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer