caa a22 4500 469026634 CHVBK 20180323132731.0 cr unu---uuuuu 170328e19921001xx s 000 0 eng 10.1007/BF01977617 doi (NATIONALLICENCE)springer-10.1007/BF01977617 Didanosine, a new antiretroviral drug [Elektronische Daten] A review [R. Franssen, P. Meenhorst, C. Koks, J. Beijnen] In this article the literature about didanosine, an antiretroviral drug, is reviewed. The mechanism of action, biochemical pharmacology, pharmacokinetics, and clinical results of phase-I trials are discussed. Serious adverse effects such as pancreatitis and peripheral neuropathy have occurred in these trials. An antiretroviral effect was observed in terms of an increase in CD4+ lymphocytes and a decrease in p24 antigen levels in HIV-infected individuals. Didanosine seems to be a promising drug against HIV infection, but knowledge about its clinical efficacy is scanty. Royal Dutch Association for Advancement of Pharmacy, 1992 Biochemistry nationallicence Didanosine nationallicence Drug evaluation nationallicence Pharmacokinetics nationallicence Pharmacology nationallicence Side effects nationallicence Franssen R. Department of Pharmacy, Slotervaart Hospital, Louwesweg 6, 1066, EC Amsterdam, The Netherlands aut Meenhorst P. Department of Internal Medicine, Slotervaart Hospital, The Netherlands aut Koks C. Department of Pharmacy, Slotervaart Hospital, Louwesweg 6, 1066, EC Amsterdam, The Netherlands aut Beijnen J. Department of Pharmacy, Slotervaart Hospital, Louwesweg 6, 1066, EC Amsterdam, The Netherlands aut Pharmaceutisch Weekblad Kluwer Academic Publishers 14/5(1992-10-01), 297-304 0031-6911 14:5<297 1992 14 11096 https://doi.org/10.1007/BF01977617 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01977617 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Franssen R. Department of Pharmacy, Slotervaart Hospital, Louwesweg 6, 1066, EC Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- Meenhorst P. Department of Internal Medicine, Slotervaart Hospital, The Netherlands aut NATIONALLICENCE 700 1- Koks C. Department of Pharmacy, Slotervaart Hospital, Louwesweg 6, 1066, EC Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- Beijnen J. Department of Pharmacy, Slotervaart Hospital, Louwesweg 6, 1066, EC Amsterdam, The Netherlands aut NATIONALLICENCE 773 0- Pharmaceutisch Weekblad Kluwer Academic Publishers 14/5(1992-10-01), 297-304 0031-6911 14:5<297 1992 14 11096 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer