caa a22 4500 469026650 CHVBK 20180323132731.0 cr unu---uuuuu 170328e19921001xx s 000 0 eng 10.1007/BF01977618 doi (NATIONALLICENCE)springer-10.1007/BF01977618 Drug transport across the blood-brain barrier [Elektronische Daten] I. Anatomical and physiological aspects [J. Van Bree, A. de Boer, M. Danhof, D. Breimer] This review describes various aspects of the transport of drugs across the blood-brain barrier and comprises three parts. In this first part, the anatomical and physiological aspects of blood-brain transport are discussed. It appears that the blood-brain barrier has an anatomical basis at the endothelium of the capillary wall. This endothelium is characterized by the presence of very tight junctions. As a result, the transport by passive diffusion of drugs with a low lipophilicity, is restricted. For certain classes of closely related relatively hydrophilic compounds, however, the presence of specialized carrier systems has been demonstrated which may facilitate transport. Also evidence is presently available, that the permeability of the blood-brain barrier may be under active regulatory control. It is expected that improved knowledge of the anatomical and physiological aspects of the blood-brain barrier and its regulation will provide a scientific basis for the development of strategies to improve the transport of drugs into the central nervous system. Royal Dutch Association for Advancement of Pharmacy, 1992 Anatomy nationallicence Biological transport nationallicence Blood-brain barrier nationallicence Carrier proteins nationallicence Cell membrane permeability nationallicence Cerebrospinal fluid nationallicence Van Bree J. Center for Bio-Pharmaceutical Sciences, Division of Pharmacology, University of Leiden, Sylvius Laboratories, P.O. Box 9503, 2300, RA Leiden, The Netherlands aut de Boer A. Center for Bio-Pharmaceutical Sciences, Division of Pharmacology, University of Leiden, Sylvius Laboratories, P.O. Box 9503, 2300, RA Leiden, The Netherlands aut Danhof M. Center for Bio-Pharmaceutical Sciences, Division of Pharmacology, University of Leiden, Sylvius Laboratories, P.O. Box 9503, 2300, RA Leiden, The Netherlands aut Breimer D. Center for Bio-Pharmaceutical Sciences, Division of Pharmacology, University of Leiden, Sylvius Laboratories, P.O. Box 9503, 2300, RA Leiden, The Netherlands aut Pharmaceutisch Weekblad Kluwer Academic Publishers 14/5(1992-10-01), 305-310 0031-6911 14:5<305 1992 14 11096 https://doi.org/10.1007/BF01977618 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01977618 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Van Bree J. Center for Bio-Pharmaceutical Sciences, Division of Pharmacology, University of Leiden, Sylvius Laboratories, P.O. Box 9503, 2300, RA Leiden, The Netherlands aut NATIONALLICENCE 700 1- de Boer A. Center for Bio-Pharmaceutical Sciences, Division of Pharmacology, University of Leiden, Sylvius Laboratories, P.O. Box 9503, 2300, RA Leiden, The Netherlands aut NATIONALLICENCE 700 1- Danhof M. Center for Bio-Pharmaceutical Sciences, Division of Pharmacology, University of Leiden, Sylvius Laboratories, P.O. Box 9503, 2300, RA Leiden, The Netherlands aut NATIONALLICENCE 700 1- Breimer D. Center for Bio-Pharmaceutical Sciences, Division of Pharmacology, University of Leiden, Sylvius Laboratories, P.O. Box 9503, 2300, RA Leiden, The Netherlands aut NATIONALLICENCE 773 0- Pharmaceutisch Weekblad Kluwer Academic Publishers 14/5(1992-10-01), 305-310 0031-6911 14:5<305 1992 14 11096 Metadata rights reserved Springer special CC-BY-NC licence nationallicence SWISSBIB 469026146 BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer