caa a22 4500 469026707 CHVBK 20180323132732.0 cr unu---uuuuu 170328e19920401xx s 000 0 eng 10.1007/BF01980480 doi (NATIONALLICENCE)springer-10.1007/BF01980480 Handling of risk-bearing drugs during pregnancy [Elektronische Daten] Do we choose less risky alternatives? [L. De Jong-Van den Berg, P. Van den Berg, F. Haaijer-Ruskamp, M. Dukes, H. Wesseling] The drug use of nearly 2,000 pregnant women was evaluated at the level of the individual patient for the drugs belonging to the Australian risk categories B3, C and D. The pattern of changes in the use of these drugs is studied in terms of women who discontinue (d), continue (c) or begin (b) using the drug during pregnancy. The ratios d/(c+b) and d/b were the highest for the drugs belonging to the high-risk groups and the lowest for drugs from the low-risk categories. This suggests a congruence between theoretical knowledge and daily practice. Patients who had already been using a drug for a long time before pregnancy, more frequently continued using that drug than patients who had been using the drug only incidentally before. The described daily dose for the riskful drugs was approximately 20% lower in patients who started to use a drug during pregnancy compared to those who continued drug use. The data from this analysis indicate that the prescribing physician is generally aware of the possible risks of drug use during pregnancy. The d/(b+c) and d/b ratios are shown to be a good measure of prescribing behaviour in relation to pregnancy and can be used to compare knowledge of theory and daily practice. Royal Dutch Association for Advancement of Pharmacy, 1992 Analgesics nationallicence Antibiotics nationallicence Anticonvulsants nationallicence Cardiovascular agents nationallicence Drug utilization nationallicence Pregnancy nationallicence Prescriptions, drug nationallicence Psychotropic drugs nationallicence Teratogens nationallicence De Jong-Van den Berg L. Department of Pharmacology and Pharmacotherapeutics, Section Pharmacy and Society, University of Groningen, Ant. Deusinglaan 2, 9713, AW Groningen, the Netherlands aut Van den Berg P. Department of Pharmacology and Pharmacotherapeutics, Section Pharmacy and Society, University of Groningen, Ant. Deusinglaan 2, 9713, AW Groningen, the Netherlands aut Haaijer-Ruskamp F. Department of Health Sciences, University of Groningen, the Netherlands aut Dukes M. Department of Health Sciences, University of Groningen, the Netherlands aut Wesseling H. Department of Pharmacology and Clinical Pharmacology, University of Groningen, the Netherlands aut Pharmaceutisch Weekblad Kluwer Academic Publishers 14/2(1992-04-01), 38-45 0031-6911 14:2<38 1992 14 11096 https://doi.org/10.1007/BF01980480 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01980480 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- De Jong-Van den Berg L. Department of Pharmacology and Pharmacotherapeutics, Section Pharmacy and Society, University of Groningen, Ant. Deusinglaan 2, 9713, AW Groningen, the Netherlands aut NATIONALLICENCE 700 1- Van den Berg P. Department of Pharmacology and Pharmacotherapeutics, Section Pharmacy and Society, University of Groningen, Ant. Deusinglaan 2, 9713, AW Groningen, the Netherlands aut NATIONALLICENCE 700 1- Haaijer-Ruskamp F. Department of Health Sciences, University of Groningen, the Netherlands aut NATIONALLICENCE 700 1- Dukes M. Department of Health Sciences, University of Groningen, the Netherlands aut NATIONALLICENCE 700 1- Wesseling H. Department of Pharmacology and Clinical Pharmacology, University of Groningen, the Netherlands aut NATIONALLICENCE 773 0- Pharmaceutisch Weekblad Kluwer Academic Publishers 14/2(1992-04-01), 38-45 0031-6911 14:2<38 1992 14 11096 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer