caa a22 4500 46902674X CHVBK 20180323132732.0 cr unu---uuuuu 170328e19920401xx s 000 0 eng 10.1007/BF01980482 doi (NATIONALLICENCE)springer-10.1007/BF01980482 Stability of total parenteral nutrition supplied as ‘all-in-one' for children with chemotherapy-linked hyperhydration [Elektronische Daten] [M. Koorenhof, J. Timmer] The maximal allowable concentrations of calcium and phosphate in total parenteral nutrition mixtures for children from one compartment were investigated. Children treated with both chemotherapy and total parenteral nutrition are supplied with high amounts of electrolytes (besides normal nutritive needs) in a restricted volume. Such nutritive mixtures are suspected of precipitation and disintegration of the lipid emulsion by (polyvalent) electrolytes, such as calcium and phosphate. Calcium (range 1.5-150 mmol/l total parenteral nutrition) and phosphate (range 21-300 mmol/l) were added to a test total parenteral nutrition mixture. After storage (24 and 48 h) at both 22°C and 37°C the mixtures were observed by microscopy for the presence of precipitates. The stability of the fat emulsion was visually assessed and the particle size distribution was measured by flow cytometry. The examined total parenteral nutrition mixtures (pH 5.4-5.7) were stable during 48 h at 37°C if the calcium concentration is below 16 mmol/l, the phosphate concentration is below 52 mmol/l and the product of both concentrations is below 250 mmol2/l2. Royal Dutch Association for Advancement of Pharmacy, 1992 Calcium phosphates nationallicence Child nationallicence Drug stability nationallicence Fat emulsions, intravenous nationallicence Parenteral feeding nationallicence Precipitation nationallicence Koorenhof M. Department of Pharmacy, Academic Medical Centre, Meibergdreef 9, 1105, AZ Amsterdam, the Netherlands aut Timmer J. Department of Pharmacy, Academic Medical Centre, Meibergdreef 9, 1105, AZ Amsterdam, the Netherlands aut Pharmaceutisch Weekblad Kluwer Academic Publishers 14/2(1992-04-01), 50-54 0031-6911 14:2<50 1992 14 11096 https://doi.org/10.1007/BF01980482 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01980482 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Koorenhof M. Department of Pharmacy, Academic Medical Centre, Meibergdreef 9, 1105, AZ Amsterdam, the Netherlands aut NATIONALLICENCE 700 1- Timmer J. Department of Pharmacy, Academic Medical Centre, Meibergdreef 9, 1105, AZ Amsterdam, the Netherlands aut NATIONALLICENCE 773 0- Pharmaceutisch Weekblad Kluwer Academic Publishers 14/2(1992-04-01), 50-54 0031-6911 14:2<50 1992 14 11096 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer