caa a22 4500 469027886 CHVBK 20180323132735.0 cr unu---uuuuu 170328e19921101xx s 000 0 eng 10.1007/BF00236389 doi (NATIONALLICENCE)springer-10.1007/BF00236389 Antimalarial activity of Artemisia annua flavonoids from whole plants and cell cultures [Elektronische Daten] [K. Liu, Shi-Lin Yang, M. Roberts, B. Elford, J. Phillipson] Summary: Cell suspension cultures developed from Artemisia annua exhibited antimalarial activity against Plasmodium faldparum in vitro both in the n-hexane extract of the plant cell culture medium and in the chloroform extract of the cells. Trace amounts of the antimalarial sesquiterpene lactone artemisinin may account for the activity of the n-hexane fraction but only the methoxylated flavonoids artemetin, chrysoplenetin, chrysosplenol-D and cirsilineol can account for the activity of the chloroform extract. These purified flavonoids were found to have IC50 values at 2.4 - 6.5 × 10−5M against P. falciparum in vitro compared with an IC50 value of about 3 × 10−8M for purified artimisinin. At concentrations of 5 × 10−6M these flavonoids were not active against P. falciparum but did have a marked and selective potentiating effect on the antiplasmodial activity of artemisinin. Springer-Verlag, 1992 Artemisia annua L nationallicence cell culture nationallicence methoxylated flavones nationallicence potentiation nationallicence artemisinin nationallicence antimalarial activity nationallicence Liu K. School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan, Peoples Republic of China aut Yang Shi-Lin Department of Pharmacognosy, The School of Pharmacy, University of London, London, UK aut Roberts M. Department of Pharmacognosy, The School of Pharmacy, University of London, London, UK aut Elford B. Institute of Molecular Medicine, OX3 9DU, Oxford, UK aut Phillipson J. Department of Pharmacognosy, The School of Pharmacy, University of London, London, UK aut Plant Cell Reports Springer-Verlag 11/12(1992-11-01), 637-640 0721-7714 11:12<637 1992 11 299 https://doi.org/10.1007/BF00236389 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00236389 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Liu K. School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan, Peoples Republic of China aut NATIONALLICENCE 700 1- Yang Shi-Lin Department of Pharmacognosy, The School of Pharmacy, University of London, London, UK aut NATIONALLICENCE 700 1- Roberts M. Department of Pharmacognosy, The School of Pharmacy, University of London, London, UK aut NATIONALLICENCE 700 1- Elford B. Institute of Molecular Medicine, OX3 9DU, Oxford, UK aut NATIONALLICENCE 700 1- Phillipson J. Department of Pharmacognosy, The School of Pharmacy, University of London, London, UK aut NATIONALLICENCE 773 0- Plant Cell Reports Springer-Verlag 11/12(1992-11-01), 637-640 0721-7714 11:12<637 1992 11 299 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer