caa a22 4500 469029943 CHVBK 20180323132740.0 cr unu---uuuuu 170328e19920701xx s 000 0 eng 10.1007/BF00402655 doi (NATIONALLICENCE)springer-10.1007/BF00402655 Effects of Cu2+, Pb2+ and Zn2+ on voltage-activated currents in Helix pomatia L. Neurons [Elektronische Daten] [O. Osipenko, T. Kiss, J. Salánki] Effects of Cu2+, Pb2+ and Zn2+ were studied on voltage-activated Na-, Ca-, and K-currents in snail neurons. It was found that: 1. In normal physiological saline Cu2+, Pb2+ and Zn2+ ions exerted complex changes on the total ionic currents; 2. All three metal ion have depressed the inward Na-currents but with different K D , moreover Pb 2+ increased Na-current at low concentrations (5 μM); 3. The inward Ca-current was also reduced. The sequence of the blocking effect of metals was different: Pb>Cu>Zn, however the steady-state inactivation was influenced only by Cu2+; 4. Outward currents were decreased in all neurons by Cu2+, but the effects of Pb2+ and Zn2+ were either depression or enhancement in different indentified neurons; 5. The possibility of binding heavy metals to wide variety of membrane proteins and the observed effects on different ionic channels suggest that the metal effect is complex and cannot be taken as a specific one to a single channel type or site of location. Kluwer Academic Publishers, 1992 Osipenko O. Balaton Limnological Research Institute of the Hungarian Academy of Sciences, Tihany, Hungary aut Kiss T. Balaton Limnological Research Institute of the Hungarian Academy of Sciences, Tihany, Hungary aut Salánki J. Balaton Limnological Research Institute of the Hungarian Academy of Sciences, Tihany, Hungary aut Environmental Monitoring and Assessment Kluwer Academic Publishers 22/1(1992-07-01), 57-72 0167-6369 22:1<57 1992 22 10661 https://doi.org/10.1007/BF00402655 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00402655 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Osipenko O. Balaton Limnological Research Institute of the Hungarian Academy of Sciences, Tihany, Hungary aut NATIONALLICENCE 700 1- Kiss T. Balaton Limnological Research Institute of the Hungarian Academy of Sciences, Tihany, Hungary aut NATIONALLICENCE 700 1- Salánki J. Balaton Limnological Research Institute of the Hungarian Academy of Sciences, Tihany, Hungary aut NATIONALLICENCE 773 0- Environmental Monitoring and Assessment Kluwer Academic Publishers 22/1(1992-07-01), 57-72 0167-6369 22:1<57 1992 22 10661 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer