caa a22 4500 469030291 CHVBK 20180323132741.0 cr unu---uuuuu 170328e19920601xx s 000 0 eng 10.1007/BF01046162 doi (NATIONALLICENCE)springer-10.1007/BF01046162 Proteoglycan and collagen morphology in superficially scarred rabbit cornea [Elektronische Daten] [Ian Rawe, Stephen Tuft, Keith Meek] Summary: We have examined the changes in collagen and proteoglycan morphology in superficial lamellar keratectomy wounds produced in rabbit corneas. The ultrastructural location within the tisse of keratan sulphate and chondroitin sulphate proteoglycans was demonstrated using the cationic dye Cuprolinic Blue under critical electrolyte conditions. Large proteoglycan filaments (up to 500 nm long) appeared in the early stages of wound healing; these were most common after two weeks' wound healing, after which they decreased both in number and size. At these early stages of scar formation, spaces containing proteoglycans were present amongst bundles of collagen fibrils. As proteoglycans play an important role in controlling corneal hydration, the presence of the large proteoglycan-filled spaces would result in an abnormally high water content which is found in early early scar tissue. Chapman & Hall, 1992 Rawe Ian Oxford Research Unit, The Open University, Foxcombe Hall, BerkeleyRoad, Boars Hill, OX1 5HR, Oxford, UK aut Tuft Stephen Moorfields Eye Hospital, City Road, EC1V 2PD, London, UK aut Meek Keith Oxford Research Unit, The Open University, Foxcombe Hall, BerkeleyRoad, Boars Hill, OX1 5HR, Oxford, UK aut The Histochemical Journal Kluwer Academic Publishers 24/6(1992-06-01), 311-318 0018-2214 24:6<311 1992 24 10735 https://doi.org/10.1007/BF01046162 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01046162 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Rawe Ian Oxford Research Unit, The Open University, Foxcombe Hall, BerkeleyRoad, Boars Hill, OX1 5HR, Oxford, UK aut NATIONALLICENCE 700 1- Tuft Stephen Moorfields Eye Hospital, City Road, EC1V 2PD, London, UK aut NATIONALLICENCE 700 1- Meek Keith Oxford Research Unit, The Open University, Foxcombe Hall, BerkeleyRoad, Boars Hill, OX1 5HR, Oxford, UK aut NATIONALLICENCE 773 0- The Histochemical Journal Kluwer Academic Publishers 24/6(1992-06-01), 311-318 0018-2214 24:6<311 1992 24 10735 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer