caa a22 4500 469030437 CHVBK 20180323132742.0 cr unu---uuuuu 170328e19920701xx s 000 0 eng 10.1007/BF01089106 doi (NATIONALLICENCE)springer-10.1007/BF01089106 Species differences in adenosine metabolic sites in the heart [Elektronische Daten] [M. Borgers, F. Thoné] Summary: 5′-Nucleotidase and purine nucleoside phosphorylase, two key enzymes in nucleoside metabolism, have been localized electronmicroscopically in left ventricular myocardium of the human, dog, pig, rabbit, guinea pig and rat. Ectonucleotidase activity was present in all species at the plasma membrane of pericytes. Reactive endothelial cells in the microcirculatory bed were restricted to those covering resistance arterioles. Cardiomyocytes were reactive only in the rat. Purine nucleoside phosphorylase was localized uniformly in the vascular endothelium of all species. The strongest activity was seen in the pericytes of guinea pig, rat and dog. Pericytes of rabbit and pig were virtually unreactive, whereas a minority of cells in human samples were positive. Cardiomyocytes were unreactive in all species. These variations in the distribution pattern of adenosine metabolic sites may have definite consequences for disposal and recovery of adenylates and their breakdown products in ischaemia and for the effects to be expected from interference with nucleoside transport inhibition. Chapman & Hall, 1992 Borgers M. Life Sciences, Janssen Research Foundation, Turnhoutseweg 30, 2340, Beerse, Belgium aut Thoné F. Life Sciences, Janssen Research Foundation, Turnhoutseweg 30, 2340, Beerse, Belgium aut The Histochemical Journal Kluwer Academic Publishers 24/7(1992-07-01), 445-452 0018-2214 24:7<445 1992 24 10735 https://doi.org/10.1007/BF01089106 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01089106 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Borgers M. Life Sciences, Janssen Research Foundation, Turnhoutseweg 30, 2340, Beerse, Belgium aut NATIONALLICENCE 700 1- Thoné F. Life Sciences, Janssen Research Foundation, Turnhoutseweg 30, 2340, Beerse, Belgium aut NATIONALLICENCE 773 0- The Histochemical Journal Kluwer Academic Publishers 24/7(1992-07-01), 445-452 0018-2214 24:7<445 1992 24 10735 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer