caa a22 4500 469030623 CHVBK 20180323132742.0 cr unu---uuuuu 170328e19921001xx s 000 0 eng 10.1007/BF01460823 doi (NATIONALLICENCE)springer-10.1007/BF01460823 Teunissen M. Departments of Dermatology and Cell Biology & Histology, Academic Medical Centre, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands aut Dynamic nature and function of epidermal langerhans cells in vivo and in vitro [Elektronische Daten] a review, with emphasis on human Langerhans cells [M. Teunissen] Summary: Epidermal Langerhans cells (LC) are Birbeck granule-containing bone-marrow-derived cells, which are located mainly in the suprabasal layer of the epidermis. They can be readily identified by their strong expression of CDIa and MHC class II molecules. In addition to these ‘classical' properties, an extensive phenotypic profile of normal human LC, summarized in this review, is now available. The powerful capacity of LC to activate T lymphocytes is clearly documented and, to date, LC are recognized as the prominent antigen-presenting cells of the skin immune system. They are generally believed to pick up antigens encountered in the epidermis and to migrate subsequently from the epidermis to the skin-draining lymph nodes. Upon arrival in the paracortex of lymph nodes, the antigen-laden LC transform into interdigitating cells and they present antigen to naive T lymphocytes in a MHC class II-restricted fashion; this results in the generation of antigen-specific immune responses. It has also been demonstrated that transformation of LC into interdigitating cells occurs when LC are culturedin vitro. Bothin vivo andin vitro studies have indicated that properties of LC, such as phenotype, morphology and the stimulatory potential to activate T lymphocytes, are dependent on the local microenvironment in which the LC reside. The essential role of LC in the induction of contact allergic skin reactions and skin transplant rejection is well established. Chapman & Hall, 1992 The Histochemical Journal Kluwer Academic Publishers 24/10(1992-10-01), 697-716 0018-2214 24:10<697 1992 24 10735 https://doi.org/10.1007/BF01460823 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01460823 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Teunissen M. Departments of Dermatology and Cell Biology & Histology, Academic Medical Centre, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands aut NATIONALLICENCE 773 0- The Histochemical Journal Kluwer Academic Publishers 24/10(1992-10-01), 697-716 0018-2214 24:10<697 1992 24 10735 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer