caa a22 4500 469031050 CHVBK 20180323132743.0 cr unu---uuuuu 170328e19921101xx s 000 0 eng 10.1007/BF01046352 doi (NATIONALLICENCE)springer-10.1007/BF01046352 A metastasis-associated antigen is present on a 60 kDa glycoprotein in transitional cell carcinoma of the human urinary bladder [Elektronische Daten] [Tetsushi Matsusako, Hisako Muramatsu, Tsutomu Shirahama, Takashi Muramatsu, Yoshitada Ohi] Summary: We have previously shown that the degree of expression of Lex-related carbohydrate epitopes, namely,Lotus tetragonolobus agglutinin (LTA) receptors, SSEA-1 and FH6, correlates with the metastatic potential of transitional cell carcinoma of the human urinary bladder. In an effort to obtain a better reagent with which to detect a metastasis-associated epitope, monoclonal antibodies were produced against LTA receptors from BOY bladder carcinoma cells. One antigen defined by such a monoclonal antibody, MM4, indeed showed better correlation with the metastatic potential of the tumour than did other carbohydrate markers. In the LTA receptors, MM4 antigen was located only on a 60 kDa glycoprotein. In extracts from primary carcinomas and lymph node metastases, the 60 kDa glycoprotein was the principal carrier of MM4 antigen. LTA receptors from these sources were composed of arrays of glycoproteins, while the 60 kDa one was invariably present. Metastasis-associated carbohydrate epitopes on the 60 kDa glycoprotein may promote metastasis by interaction with carbohydrate-recognizing proteins such as selectins on host cells. Chapman & Hall, 1992 Matsusako Tetsushi Department of Urology, Faculty of Medicine, Kagoshima University, 8-35-1 Sakuragaoka, 890, Kagoshima, Japan aut Muramatsu Hisako Department of Biochemistry, Faculty of Medicine, Kagoshima University, 8-35-1 Sakuragaoka, 890, Kagoshima, Japan aut Shirahama Tsutomu Department of Urology, Faculty of Medicine, Kagoshima University, 8-35-1 Sakuragaoka, 890, Kagoshima, Japan aut Muramatsu Takashi Department of Biochemistry, Faculty of Medicine, Kagoshima University, 8-35-1 Sakuragaoka, 890, Kagoshima, Japan aut Ohi Yoshitada Department of Urology, Faculty of Medicine, Kagoshima University, 8-35-1 Sakuragaoka, 890, Kagoshima, Japan aut The Histochemical Journal Kluwer Academic Publishers 24/11(1992-11-01), 805-810 0018-2214 24:11<805 1992 24 10735 https://doi.org/10.1007/BF01046352 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01046352 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Matsusako Tetsushi Department of Urology, Faculty of Medicine, Kagoshima University, 8-35-1 Sakuragaoka, 890, Kagoshima, Japan aut NATIONALLICENCE 700 1- Muramatsu Hisako Department of Biochemistry, Faculty of Medicine, Kagoshima University, 8-35-1 Sakuragaoka, 890, Kagoshima, Japan aut NATIONALLICENCE 700 1- Shirahama Tsutomu Department of Urology, Faculty of Medicine, Kagoshima University, 8-35-1 Sakuragaoka, 890, Kagoshima, Japan aut NATIONALLICENCE 700 1- Muramatsu Takashi Department of Biochemistry, Faculty of Medicine, Kagoshima University, 8-35-1 Sakuragaoka, 890, Kagoshima, Japan aut NATIONALLICENCE 700 1- Ohi Yoshitada Department of Urology, Faculty of Medicine, Kagoshima University, 8-35-1 Sakuragaoka, 890, Kagoshima, Japan aut NATIONALLICENCE 773 0- The Histochemical Journal Kluwer Academic Publishers 24/11(1992-11-01), 805-810 0018-2214 24:11<805 1992 24 10735 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer