caa a22 4500 469031115 CHVBK 20180323132744.0 cr unu---uuuuu 170328e19921101xx s 000 0 eng 10.1007/BF01046361 doi (NATIONALLICENCE)springer-10.1007/BF01046361 Expression of the CD15 epitope in the human magnocellular basal forebrain system [Elektronische Daten] [S. Morres, J. Mai, L. Teckhaus] Summary: The distribution of the carbohydrate epitope 3-fucosyl-N-acetyl-lactosamine (CD15) has been immunocytochemically evaluated in coronal paraffin sections through the magnocellular basal forebrain system—the nucleus basalis of Meynert, the nucleus of the diagonal band of Broca and the medial septal nucleus-of 202 human brains. The brains derived from differently aged controls (n=54) and from patients suffering from organic brain diseases (n=129), or psychiatric disorders (n=19). In 30 cases dementia was clinically diagnosed. CD15 first appeared around birth when it became localized on singular astrocytes. The astrocyte number and process density steadily increased, and at approximately 12 years the typical adult-type pattern was acquired. Considerable variations in the expression patterns were noted with regard to the astrocyte number, the intensity in immunostaining and the process relations of CD15-positive astrocytes with the magnocellular neurons. In the light of these variations, and of conflicting additional changes in other areas of most diseased brains, it was difficult to correlate different intensities and patterns to specific diseases. The results, however, provide evidence for an increase in CD15 expression and in process network density of astrocytes in the lateral part of the nucleus basalis of Meynert in cases of Huntington's disease. Chapman & Hall, 1992 Morres S. Department of Neuropathology, Heinrich-Heine University of Düsseldorf, Düsseldorf, Germany aut Mai J. Department of Neuroanatomy, Heinrich-Heine University of Düsseldorf, Moorenstr. 5, D-4000, Düsseldorf 1, Germany aut Teckhaus L. Max-Planck-Institute for Systems Physiology, Dortmund, Germany aut The Histochemical Journal Kluwer Academic Publishers 24/11(1992-11-01), 902-909 0018-2214 24:11<902 1992 24 10735 https://doi.org/10.1007/BF01046361 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01046361 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Morres S. Department of Neuropathology, Heinrich-Heine University of Düsseldorf, Düsseldorf, Germany aut NATIONALLICENCE 700 1- Mai J. Department of Neuroanatomy, Heinrich-Heine University of Düsseldorf, Moorenstr. 5, D-4000, Düsseldorf 1, Germany aut NATIONALLICENCE 700 1- Teckhaus L. Max-Planck-Institute for Systems Physiology, Dortmund, Germany aut NATIONALLICENCE 773 0- The Histochemical Journal Kluwer Academic Publishers 24/11(1992-11-01), 902-909 0018-2214 24:11<902 1992 24 10735 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer