caa a22 4500 469031131 CHVBK 20180323132744.0 cr unu---uuuuu 170328e19921101xx s 000 0 eng 10.1007/BF01046351 doi (NATIONALLICENCE)springer-10.1007/BF01046351 Glycoproteins and lectins in cell adhesion and cell recognition processes [Elektronische Daten] [Jean-Pierre Zanetta, Sabine Kuchler, Sylvain Lehmann, Ali Badache, Susanna Maschke, Didier Thomas, Pascale Dufourcq, Guy Vincendon] Summary: The discovery of endogenous lectins having specific and high affinity for the carbohydrate portions of glycoproteins has opened up new directions in the field of cell adhesion and cell recognition. Two endogenous lectins, termed as CSL and R1, initially isolated from the rat cerebellum and having a wide distribution in mammalian tissues, have been shown to participate in essential mechanisms of cell adhesion. The membrane-bound lectin R1 seems to be involved in transient recognition between neuronal cells, followed by elimination of the glycoprotein ligands at the surface of the recognized cell. In contrast, CSL is a molecule involved in adhesion between various normal or transformed cells since it participates in the formation of tight junctions. The glycoprotein ligands recognized with higher affinity by these two lectins seem to possess a special structure which defines a sub-class of oncofetal HNK-1 glycans. The over-expression of the glycoprotein ligands of these lectins in most transformed cells provides new tools for understanding the underlying mechanism of malignant transformation as well as the generation of signals through cell adhesion. Chapman & Hall, 1992 Zanetta Jean-Pierre Laboratoire de Neurobiologie Moléculaire des Interactions Cellulaires, CNRS UPR 416, Centre de Neurochimie du CNRS, 5 rue Blaise Pascal, 67000, Strasbourg, France aut Kuchler Sabine Laboratoire de Neurobiologie Moléculaire des Interactions Cellulaires, CNRS UPR 416, Centre de Neurochimie du CNRS, 5 rue Blaise Pascal, 67000, Strasbourg, France aut Lehmann Sylvain Laboratoire de Neurobiologie Moléculaire des Interactions Cellulaires, CNRS UPR 416, Centre de Neurochimie du CNRS, 5 rue Blaise Pascal, 67000, Strasbourg, France aut Badache Ali Laboratoire de Neurobiologie Moléculaire des Interactions Cellulaires, CNRS UPR 416, Centre de Neurochimie du CNRS, 5 rue Blaise Pascal, 67000, Strasbourg, France aut Maschke Susanna Laboratoire de Neurobiologie Moléculaire des Interactions Cellulaires, CNRS UPR 416, Centre de Neurochimie du CNRS, 5 rue Blaise Pascal, 67000, Strasbourg, France aut Thomas Didier Laboratoire de Neurobiologie Moléculaire des Interactions Cellulaires, CNRS UPR 416, Centre de Neurochimie du CNRS, 5 rue Blaise Pascal, 67000, Strasbourg, France aut Dufourcq Pascale Laboratoire de Neurobiologie Moléculaire des Interactions Cellulaires, CNRS UPR 416, Centre de Neurochimie du CNRS, 5 rue Blaise Pascal, 67000, Strasbourg, France aut Vincendon Guy Laboratoire de Neurobiologie Moléculaire des Interactions Cellulaires, CNRS UPR 416, Centre de Neurochimie du CNRS, 5 rue Blaise Pascal, 67000, Strasbourg, France aut The Histochemical Journal Kluwer Academic Publishers 24/11(1992-11-01), 791-804 0018-2214 24:11<791 1992 24 10735 https://doi.org/10.1007/BF01046351 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01046351 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zanetta Jean-Pierre Laboratoire de Neurobiologie Moléculaire des Interactions Cellulaires, CNRS UPR 416, Centre de Neurochimie du CNRS, 5 rue Blaise Pascal, 67000, Strasbourg, France aut NATIONALLICENCE 700 1- Kuchler Sabine Laboratoire de Neurobiologie Moléculaire des Interactions Cellulaires, CNRS UPR 416, Centre de Neurochimie du CNRS, 5 rue Blaise Pascal, 67000, Strasbourg, France aut NATIONALLICENCE 700 1- Lehmann Sylvain Laboratoire de Neurobiologie Moléculaire des Interactions Cellulaires, CNRS UPR 416, Centre de Neurochimie du CNRS, 5 rue Blaise Pascal, 67000, Strasbourg, France aut NATIONALLICENCE 700 1- Badache Ali Laboratoire de Neurobiologie Moléculaire des Interactions Cellulaires, CNRS UPR 416, Centre de Neurochimie du CNRS, 5 rue Blaise Pascal, 67000, Strasbourg, France aut NATIONALLICENCE 700 1- Maschke Susanna Laboratoire de Neurobiologie Moléculaire des Interactions Cellulaires, CNRS UPR 416, Centre de Neurochimie du CNRS, 5 rue Blaise Pascal, 67000, Strasbourg, France aut NATIONALLICENCE 700 1- Thomas Didier Laboratoire de Neurobiologie Moléculaire des Interactions Cellulaires, CNRS UPR 416, Centre de Neurochimie du CNRS, 5 rue Blaise Pascal, 67000, Strasbourg, France aut NATIONALLICENCE 700 1- Dufourcq Pascale Laboratoire de Neurobiologie Moléculaire des Interactions Cellulaires, CNRS UPR 416, Centre de Neurochimie du CNRS, 5 rue Blaise Pascal, 67000, Strasbourg, France aut NATIONALLICENCE 700 1- Vincendon Guy Laboratoire de Neurobiologie Moléculaire des Interactions Cellulaires, CNRS UPR 416, Centre de Neurochimie du CNRS, 5 rue Blaise Pascal, 67000, Strasbourg, France aut NATIONALLICENCE 773 0- The Histochemical Journal Kluwer Academic Publishers 24/11(1992-11-01), 791-804 0018-2214 24:11<791 1992 24 10735 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer