caa a22 4500 469032669 CHVBK 20180323132747.0 cr unu---uuuuu 170328e19920401xx s 000 0 eng 10.1007/BF00179791 doi (NATIONALLICENCE)springer-10.1007/BF00179791 An approach to the localization of the susceptibility genes for generalized myasthenia gravis by mapping recombinant ancestral haplotypes [Elektronische Daten] [Mariapia Degli-Esposti, Adriane Andreas, Frank Christiansen, Bernd Schalke, Ekkehard Albert, Roger Dawkins] The association of HLA A1, B8, and DR3 with generalized myasthenia gravis (GMG) ini Caucasoids is well established, but no particular gene has been implicated and there is still no adequate explanation in functional terms. In study we have taken advantage of sequential genomic markers between B8 and DR3 so as to map the location of susceptibility gene(s) on the A1, B8, DR3 (8.1) ancestral haplotype. By studying 51 patients, we have delineated a region between HLA B and TNF which is shared by 29/29 patients with B8 and DR3, 19/19 patients with B8 but not DR3 and 2/3 patients with DR3 but not B8. The potential importance of this region was confirmed by examining a similar disease induced by D-Penicillamine (D-PenMG) and associated with different HLA class II alleles (DR1 and/or DR7). Among these patients, 7/16 (44%) have B8, often with other markers of 8.1. These results implicate at least two categories of genes in determining susceptibility to MG; one located in the region between HLA B and TNF may be immunoregulatory, whereas the second, located in the class II region, may relate to the inducing factor (e. g., DR1 or DR7 in D-PenMG). Springer-Verlag, 1992 Degli-Esposti Mariapia Department of Clinical Immunology, Royal Perth Hospital, Perth, Western Australia aut Andreas Adriane Immunogenetics Laboratory, Kinderpoliklinik der Universität, Munich, Germany aut Christiansen Frank Department of Clinical Immunology, Royal Perth Hospital, Perth, Western Australia aut Schalke Bernd Department of Neurology, University of Wüzburg, Wüzburg, Germany aut Albert Ekkehard Immunogenetics Laboratory, Kinderpoliklinik der Universität, Munich, Germany aut Dawkins Roger Department of Clinical Immunology, Royal Perth Hospital, Perth, Western Australia aut Immunogenetics Springer-Verlag 35/6(1992-04-01), 355-364 0093-7711 35:6<355 1992 35 251 https://doi.org/10.1007/BF00179791 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00179791 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Degli-Esposti Mariapia Department of Clinical Immunology, Royal Perth Hospital, Perth, Western Australia aut NATIONALLICENCE 700 1- Andreas Adriane Immunogenetics Laboratory, Kinderpoliklinik der Universität, Munich, Germany aut NATIONALLICENCE 700 1- Christiansen Frank Department of Clinical Immunology, Royal Perth Hospital, Perth, Western Australia aut NATIONALLICENCE 700 1- Schalke Bernd Department of Neurology, University of Wüzburg, Wüzburg, Germany aut NATIONALLICENCE 700 1- Albert Ekkehard Immunogenetics Laboratory, Kinderpoliklinik der Universität, Munich, Germany aut NATIONALLICENCE 700 1- Dawkins Roger Department of Clinical Immunology, Royal Perth Hospital, Perth, Western Australia aut NATIONALLICENCE 773 0- Immunogenetics Springer-Verlag 35/6(1992-04-01), 355-364 0093-7711 35:6<355 1992 35 251 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer