caa a22 4500 469032707 CHVBK 20180323132747.0 cr unu---uuuuu 170328e19920201xx s 000 0 eng 10.1007/BF00185109 doi (NATIONALLICENCE)springer-10.1007/BF00185109 Immunogenetics of human minor histocompatibility antigens: their polymorphism and immunodominance [Elektronische Daten] [C. van Els, J. D'Amaro, J. Pool, E. Blokland, A. Bakker, P. van Elsen, J. van Rood, E. Goulmy] Minor Histocompatibility (mH) antigens are polymorphic endogenously synthesized products that can be recognized by alloreactive T cells in the context of major histocompatibility complex molecules. In transplant situations where tissue donor and recipient are matched for HLA, mH antigens may trigger strong cellular immune responses. To gain insight into the polymorphism of mH antigens we studied their frequencies in the healthy population. Five HLA class I restricted mH antigens recognized by distinct cytotoxic T-cell (CTL) clones were used in the population genetic analysis consisting of a panel (N=100) of HLA typed target cells. Three mH antigens showed phenotype frequencies of 69% or higher, this contrasted the frequencies of two other mH antigens with 16 and 7% respectively. To gain insight into the "functional” polymorphism of the T-cell response to mH antigens, we analyzed the specificity of CTL clones within individuals. Three out of five individuals investigated shared a CTL response to one single HLA-A2 restricted mH antigen. These results indicate limited allelic polymorphism for some mH antigens in the healthy population and are suggestive of the existence of immunodominant human mH antigens. Springer-Verlag, 1992 van Els C. Department for Immunobiology, RIVM, P. O. Box 1, 3720, Bilthoven, BA, the Netherlands aut D'Amaro J. Department of Immunohaematology and Blood Bank, University Hospital Leiden, P. O. Box 9600, 2300, Leiden, RC aut Pool J. Department of Immunohaematology and Blood Bank, University Hospital Leiden, P. O. Box 9600, 2300, Leiden, RC aut Blokland E. Department of Immunohaematology and Blood Bank, University Hospital Leiden, P. O. Box 9600, 2300, Leiden, RC aut Bakker A. Department of Immunohaematology and Blood Bank, University Hospital Leiden, P. O. Box 9600, 2300, Leiden, RC aut van Elsen P. Department of Immunohaematology and Blood Bank, University Hospital Leiden, P. O. Box 9600, 2300, Leiden, RC aut van Rood J. Department of Immunohaematology and Blood Bank, University Hospital Leiden, P. O. Box 9600, 2300, Leiden, RC aut Goulmy E. Department of Immunohaematology and Blood Bank, University Hospital Leiden, P. O. Box 9600, 2300, Leiden, RC aut Immunogenetics Springer-Verlag 35/3(1992-02-01), 161-165 0093-7711 35:3<161 1992 35 251 https://doi.org/10.1007/BF00185109 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00185109 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- van Els C. Department for Immunobiology, RIVM, P. O. Box 1, 3720, Bilthoven, BA, the Netherlands aut NATIONALLICENCE 700 1- D'Amaro J. Department of Immunohaematology and Blood Bank, University Hospital Leiden, P. O. Box 9600, 2300, Leiden, RC aut NATIONALLICENCE 700 1- Pool J. Department of Immunohaematology and Blood Bank, University Hospital Leiden, P. O. Box 9600, 2300, Leiden, RC aut NATIONALLICENCE 700 1- Blokland E. Department of Immunohaematology and Blood Bank, University Hospital Leiden, P. O. Box 9600, 2300, Leiden, RC aut NATIONALLICENCE 700 1- Bakker A. Department of Immunohaematology and Blood Bank, University Hospital Leiden, P. O. Box 9600, 2300, Leiden, RC aut NATIONALLICENCE 700 1- van Elsen P. Department of Immunohaematology and Blood Bank, University Hospital Leiden, P. O. Box 9600, 2300, Leiden, RC aut NATIONALLICENCE 700 1- van Rood J. Department of Immunohaematology and Blood Bank, University Hospital Leiden, P. O. Box 9600, 2300, Leiden, RC aut NATIONALLICENCE 700 1- Goulmy E. Department of Immunohaematology and Blood Bank, University Hospital Leiden, P. O. Box 9600, 2300, Leiden, RC aut NATIONALLICENCE 773 0- Immunogenetics Springer-Verlag 35/3(1992-02-01), 161-165 0093-7711 35:3<161 1992 35 251 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer