caa a22 4500 469032774 CHVBK 20180323132748.0 cr unu---uuuuu 170328e19920201xx s 000 0 eng 10.1007/BF00185112 doi (NATIONALLICENCE)springer-10.1007/BF00185112 A continuous restriction map from HLA-E to HLA-F [Elektronische Daten] Structural comparison between different HLA-A haplotypes [Abdel El Kahloun, Corine Vernet, Anne-Marie Jouanolle, Joëlle Boretto, Valérie Mauvieux, Jean-Yves Le Gall, Véronique David, Pierre Pontarotti] The class I region of the human major histocompatibility complex contains genes encoding the classical transplantation antigens (HLA-A, B, and C), at least three new class I genes (HLA-E, F, and G) and many class I pseudogenes (including HLA-H). By pulse field gel electrophoresis and using five rare cutter enzymes, we have constructed a precise and continuous map of 1200 kilobases (kb) around HLA-A. The blots were hybridized with HLA-A, E, and F-specific probes and with new probes derived from yeast artificial chromosomes and cosmids of the class I region. We have compared the genomic organization of the same 1200 kb in three homozygous lymphoblastoid cell lines corresponding to three different HLA haplotypes (A3, A24, and A31). The differences in size observed may have been caused by insertions and deletions and may prove valuable in understanding the evolution of the HLA chromosomal region. Springer-Verlag, 1992 El Kahloun Abdel Laboratoire de Biochimie Médicale B. Faculté de Médecine, F-35043, Rennes Cédex, France aut Vernet Corine C.I.M.L., F-13288, Marseille Cédex 9, France aut Jouanolle Anne-Marie Laboratoire de Biochimie Médicale B. Faculté de Médecine, F-35043, Rennes Cédex, France aut Boretto Joëlle C.I.M.L., F-13288, Marseille Cédex 9, France aut Mauvieux Valérie Laboratoire de Biochimie Médicale B. Faculté de Médecine, F-35043, Rennes Cédex, France aut Le Gall Jean-Yves Laboratoire de Biochimie Médicale B. Faculté de Médecine, F-35043, Rennes Cédex, France aut David Véronique Laboratoire de Biochimie Médicale B. Faculté de Médecine, F-35043, Rennes Cédex, France aut Pontarotti Pierre C.I.M.L., F-13288, Marseille Cédex 9, France aut Immunogenetics Springer-Verlag 35/3(1992-02-01), 183-189 0093-7711 35:3<183 1992 35 251 https://doi.org/10.1007/BF00185112 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00185112 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- El Kahloun Abdel Laboratoire de Biochimie Médicale B. Faculté de Médecine, F-35043, Rennes Cédex, France aut NATIONALLICENCE 700 1- Vernet Corine C.I.M.L., F-13288, Marseille Cédex 9, France aut NATIONALLICENCE 700 1- Jouanolle Anne-Marie Laboratoire de Biochimie Médicale B. Faculté de Médecine, F-35043, Rennes Cédex, France aut NATIONALLICENCE 700 1- Boretto Joëlle C.I.M.L., F-13288, Marseille Cédex 9, France aut NATIONALLICENCE 700 1- Mauvieux Valérie Laboratoire de Biochimie Médicale B. Faculté de Médecine, F-35043, Rennes Cédex, France aut NATIONALLICENCE 700 1- Le Gall Jean-Yves Laboratoire de Biochimie Médicale B. Faculté de Médecine, F-35043, Rennes Cédex, France aut NATIONALLICENCE 700 1- David Véronique Laboratoire de Biochimie Médicale B. Faculté de Médecine, F-35043, Rennes Cédex, France aut NATIONALLICENCE 700 1- Pontarotti Pierre C.I.M.L., F-13288, Marseille Cédex 9, France aut NATIONALLICENCE 773 0- Immunogenetics Springer-Verlag 35/3(1992-02-01), 183-189 0093-7711 35:3<183 1992 35 251 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer