caa a22 4500 469032812 CHVBK 20180323132748.0 cr unu---uuuuu 170328e19920301xx s 000 0 eng 10.1007/BF00166828 doi (NATIONALLICENCE)springer-10.1007/BF00166828 DNA sequences near a meiotic recombinational breakpoint within the human HLA-DQ region [Elektronische Daten] [Karuturi Satyanarayana, Jack Strominger] The molecular organization of HLA-DQ regions derived from DR7, DQw2, and DR4, DQw3 parental haplotypes and DR7, DQw3, a presumed recombinant haplotype, have been studied to define the sequences between DQA1 and DQB1 which may have been involved in this recombinational event. The breakpoint was localized in the intergenic region near the 3′ end of the DQB1 gene by restriction mapping. DNA sequences in the immediate vicinity of the breakpoint in DR7, DQw2 (parental), and DR7, DQw3 (recombinant) haplotypes revealed the presence of (CA)22 repeats, minisatellite-related sequences and GC-rich sequences. The intergenic regions varied considerably depending on the haplotype and contained several additional types of repetitive sequences including Alu and LINE repeats. Some of these sequences are related to sequences previously suggested to be involved in meiotic or somatic recombination. In particular, (CA)n repeats, which can adopt the Z-DNA conformation, have previously been shown to promote recombination in several systems. Springer-Verlag, 1992 Satyanarayana Karuturi Department of Biochemistry and Molecular Biology, Harvard University, 7 Divinity Avenue, 02138, Cambridge, MA, USA aut Strominger Jack Department of Biochemistry and Molecular Biology, Harvard University, 7 Divinity Avenue, 02138, Cambridge, MA, USA aut Immunogenetics Springer-Verlag 35/4(1992-03-01), 235-240 0093-7711 35:4<235 1992 35 251 https://doi.org/10.1007/BF00166828 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00166828 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Satyanarayana Karuturi Department of Biochemistry and Molecular Biology, Harvard University, 7 Divinity Avenue, 02138, Cambridge, MA, USA aut NATIONALLICENCE 700 1- Strominger Jack Department of Biochemistry and Molecular Biology, Harvard University, 7 Divinity Avenue, 02138, Cambridge, MA, USA aut NATIONALLICENCE 773 0- Immunogenetics Springer-Verlag 35/4(1992-03-01), 235-240 0093-7711 35:4<235 1992 35 251 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer