caa a22 4500 46903288X CHVBK 20180323132748.0 cr unu---uuuuu 170328e19920301xx s 000 0 eng 10.1007/BF00166833 doi (NATIONALLICENCE)springer-10.1007/BF00166833 Search for MHC-associated genes in human: five new genes centromeric to HLA-DP with yet unknown functions [Elektronische Daten] [Mahmoud Janatipour, Yuri Naumov, Asako Ando, Kazuhito Sugimura, Naoaki Okamoto, Kimiyoshi Tsuji, Kuniya Abe, Hidetoshi Inoko] Taking advantage of five mouse genomic or cDNA probes [KE5(probe 14), KE4 (probe11), KE3 (probe7), KE2 (probe5), and SET] mapped on the H-2K region in mouse, we have identified and localized homologues of these five genes in the human major histocompatibility complex region (HKE5, HKE4, HKE3, HKE2, and HSET, respectively). Cosmid cloning and pulsed field gel electrophoresis analyses indicated that a human homologous gene, HKE5, is located 10 kilobases (kb) centromeric of the α2(XI) collagen (COL11A2) gene followed by HKE4. HKE3, closely linked to HKE2, is located 170 kb centromeric of HKE4. Furthermore, HSET is located 50 kb centromeric of HKE2. This gene organization outside the DP subregion is completely identical to that of the mouse H-2K region centromeric of I-Pb 3, a mouse homologue of the DPB gene, except the lack of genes corresponding to the H-2K and -K2 genes in human. Springer-Verlag, 1992 Janatipour Mahmoud Department of Transplantation II, Tokai University School of Medicine, Bohseidai, 259-11, Isehara, Japan aut Naumov Yuri Department of Transplantation II, Tokai University School of Medicine, Bohseidai, 259-11, Isehara, Japan aut Ando Asako Department of Transplantation II, Tokai University School of Medicine, Bohseidai, 259-11, Isehara, Japan aut Sugimura Kazuhito Department of Transplantation II, Tokai University School of Medicine, Bohseidai, 259-11, Isehara, Japan aut Okamoto Naoaki Department of Transplantation II, Tokai University School of Medicine, Bohseidai, 259-11, Isehara, Japan aut Tsuji Kimiyoshi Department of Transplantation II, Tokai University School of Medicine, Bohseidai, 259-11, Isehara, Japan aut Abe Kuniya Furusawa Morpho Gene Project, ERATO, Research Development Corporation of Japan (JRDC), 305, Tsukuba, Japan aut Inoko Hidetoshi Department of Transplantation II, Tokai University School of Medicine, Bohseidai, 259-11, Isehara, Japan aut Immunogenetics Springer-Verlag 35/4(1992-03-01), 272-278 0093-7711 35:4<272 1992 35 251 https://doi.org/10.1007/BF00166833 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00166833 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Janatipour Mahmoud Department of Transplantation II, Tokai University School of Medicine, Bohseidai, 259-11, Isehara, Japan aut NATIONALLICENCE 700 1- Naumov Yuri Department of Transplantation II, Tokai University School of Medicine, Bohseidai, 259-11, Isehara, Japan aut NATIONALLICENCE 700 1- Ando Asako Department of Transplantation II, Tokai University School of Medicine, Bohseidai, 259-11, Isehara, Japan aut NATIONALLICENCE 700 1- Sugimura Kazuhito Department of Transplantation II, Tokai University School of Medicine, Bohseidai, 259-11, Isehara, Japan aut NATIONALLICENCE 700 1- Okamoto Naoaki Department of Transplantation II, Tokai University School of Medicine, Bohseidai, 259-11, Isehara, Japan aut NATIONALLICENCE 700 1- Tsuji Kimiyoshi Department of Transplantation II, Tokai University School of Medicine, Bohseidai, 259-11, Isehara, Japan aut NATIONALLICENCE 700 1- Abe Kuniya Furusawa Morpho Gene Project, ERATO, Research Development Corporation of Japan (JRDC), 305, Tsukuba, Japan aut NATIONALLICENCE 700 1- Inoko Hidetoshi Department of Transplantation II, Tokai University School of Medicine, Bohseidai, 259-11, Isehara, Japan aut NATIONALLICENCE 773 0- Immunogenetics Springer-Verlag 35/4(1992-03-01), 272-278 0093-7711 35:4<272 1992 35 251 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer