caa a22 4500 469032944 CHVBK 20180323132748.0 cr unu---uuuuu 170328e19920301xx s 000 0 eng 10.1007/BF00189891 doi (NATIONALLICENCE)springer-10.1007/BF00189891 Tomonari Kyuhei Transplantation Biology Section, MRC Clinical Research Centre, Watford Road, Harrow, HA1 3UJ, Middlesex, England aut Negative selection of Tcra-V8+CD8+ T cells by MHC class I molecules [Elektronische Daten] [Kyuhei Tomonari] Tcrb-V-specific positive and negative selection of T cells has been well documented. In contrast, nothing is known about Tcra-V-specific selection. Using Tcra-V8-specific KT50 antibody Tcra-V8-specific selection of T cells has been examined. The CD8+ T cell subpopulation bearing Tcra-V8 are shown to be negatively selected by major histocompatibility complex (MHC) class I H-2Kd and H-2Dd/Ld molecules. Furthermore, percentages of these T cells are also influenced by Tcra-V haplotypes. Involvement of non-H-2 self (super)antigens in this MHC class I restricted negative selection, however, remains to be determined. Springer-Verlag, 1992 Immunogenetics Springer-Verlag 35/5(1992-03-01), 291-295 0093-7711 35:5<291 1992 35 251 https://doi.org/10.1007/BF00189891 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00189891 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Tomonari Kyuhei Transplantation Biology Section, MRC Clinical Research Centre, Watford Road, Harrow, HA1 3UJ, Middlesex, England aut NATIONALLICENCE 773 0- Immunogenetics Springer-Verlag 35/5(1992-03-01), 291-295 0093-7711 35:5<291 1992 35 251 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer