caa a22 4500 469033045 CHVBK 20180323132748.0 cr unu---uuuuu 170328e19920101xx s 000 0 eng 10.1007/BF00189516 doi (NATIONALLICENCE)springer-10.1007/BF00189516 Sequence and diversity of rhesus monkey T-cell receptor β chain genes [Elektronische Daten] [Gene Levinson, Austin Hughes, Norman Letvin] We have sequenced 23 rearranged T-cell receptor β chain (Tcrb) cDNA clones derived from peripheral blood lymphocytes (PBL) of a rhesus monkey. All of the clones have a variable-diversity-joining-constant (V-D-J-C) rearrangement similar to that of humans. Two rhesus constant (C) region genes were found, each closely reasembling human Cb 1 and 2. All of the rhesus J region sequences align well with ten of the 13 reported human J regions. 17 of the 23 rhesus V region sequences could be assigned to families homologous with eight different human families (Vb 1, 2, 6, 7, 8, 9, 13, and 14). The remaining six V region sequences are more distantly related to human Vb 1 and 13. Thus, the organization and sequences of studied rhesus Tcrb chains resemble human homologs. An evolutionary tree analysis revealed paralogous relationships between specific members of the rhesus and human V region families. Analysis of synonymous and nonsynonymous nucleotide sequence differences indicated that the evolution of the presumed major histocompatibility complex (MHC)-contact regions of the Tcrb chains is less constrained than that of the framework regions. Springer-Verlag, 1992 Levinson Gene New England Regional Primate Research Center, Harvard Medical School, One Pine Hill Drive, 01772, Southborough, MA, USA aut Hughes Austin Department of Biology, The Pennsylvania State University, 16802, University Park, PA, USA aut Letvin Norman New England Regional Primate Research Center, Harvard Medical School, One Pine Hill Drive, 01772, Southborough, MA, USA aut Immunogenetics Springer-Verlag 35/2(1992-01-01), 75-88 0093-7711 35:2<75 1992 35 251 https://doi.org/10.1007/BF00189516 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00189516 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Levinson Gene New England Regional Primate Research Center, Harvard Medical School, One Pine Hill Drive, 01772, Southborough, MA, USA aut NATIONALLICENCE 700 1- Hughes Austin Department of Biology, The Pennsylvania State University, 16802, University Park, PA, USA aut NATIONALLICENCE 700 1- Letvin Norman New England Regional Primate Research Center, Harvard Medical School, One Pine Hill Drive, 01772, Southborough, MA, USA aut NATIONALLICENCE 773 0- Immunogenetics Springer-Verlag 35/2(1992-01-01), 75-88 0093-7711 35:2<75 1992 35 251 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer