caa a22 4500 46903307X CHVBK 20180323132748.0 cr unu---uuuuu 170328e19920101xx s 000 0 eng 10.1007/BF00189518 doi (NATIONALLICENCE)springer-10.1007/BF00189518 The recombination activating genes, RAG 1 and RAG 2 , are on chromosome 11p in humans and chromosome 2p in mice [Elektronische Daten] [Marjorie Oettinger, Ben Stanger, David Schatz, Tom Glaser, Kathy Call, David Housman, David Baltimore] The recombination activating genes RAG-1 and RAG-2 are adjacent genes that act synergistically to activate variable-diversity-joining (V(D)J) recombination. Southern analysis of hybrid cell lines derived from patients with the Wilms tumor-aniridia-genitourinary defects-mental retardation (WAGR) syndrome and from mutagenized cell hybrids selected for deletions in chromosome 11 has allowed us to map the chromosomal location of the human RAG locus. The RAG locus defines a new interval of human chromosome 11p, but is not associated with any genetically mapped human disease. Guided by the chromosomal localization of the human recombination activating genes, we have also mapped the location of the mouse Rag locus. Springer-Verlag, 1992 Oettinger Marjorie The Whitehead Institute for Biomedical Research, 9 Cambridge Center, 02142, Cambridge, MA, USA aut Stanger Ben Center for Cancer Research, Massachusetts Institute of Technology, 02139, Cambridge, MA, USA aut Schatz David The Whitehead Institute for Biomedical Research, 9 Cambridge Center, 02142, Cambridge, MA, USA aut Glaser Tom Center for Cancer Research, Massachusetts Institute of Technology, 02139, Cambridge, MA, USA aut Call Kathy Center for Cancer Research, Massachusetts Institute of Technology, 02139, Cambridge, MA, USA aut Housman David Center for Cancer Research, Massachusetts Institute of Technology, 02139, Cambridge, MA, USA aut Baltimore David The Whitehead Institute for Biomedical Research, 9 Cambridge Center, 02142, Cambridge, MA, USA aut Immunogenetics Springer-Verlag 35/2(1992-01-01), 97-101 0093-7711 35:2<97 1992 35 251 https://doi.org/10.1007/BF00189518 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00189518 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Oettinger Marjorie The Whitehead Institute for Biomedical Research, 9 Cambridge Center, 02142, Cambridge, MA, USA aut NATIONALLICENCE 700 1- Stanger Ben Center for Cancer Research, Massachusetts Institute of Technology, 02139, Cambridge, MA, USA aut NATIONALLICENCE 700 1- Schatz David The Whitehead Institute for Biomedical Research, 9 Cambridge Center, 02142, Cambridge, MA, USA aut NATIONALLICENCE 700 1- Glaser Tom Center for Cancer Research, Massachusetts Institute of Technology, 02139, Cambridge, MA, USA aut NATIONALLICENCE 700 1- Call Kathy Center for Cancer Research, Massachusetts Institute of Technology, 02139, Cambridge, MA, USA aut NATIONALLICENCE 700 1- Housman David Center for Cancer Research, Massachusetts Institute of Technology, 02139, Cambridge, MA, USA aut NATIONALLICENCE 700 1- Baltimore David The Whitehead Institute for Biomedical Research, 9 Cambridge Center, 02142, Cambridge, MA, USA aut NATIONALLICENCE 773 0- Immunogenetics Springer-Verlag 35/2(1992-01-01), 97-101 0093-7711 35:2<97 1992 35 251 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer