caa a22 4500 469033096 CHVBK 20180323132749.0 cr unu---uuuuu 170328e19920101xx s 000 0 eng 10.1007/BF00189519 doi (NATIONALLICENCE)springer-10.1007/BF00189519 Structure of the genes encoding the CD19 antigen of human and mouse B lymphocytes [Elektronische Daten] [Liang-Ji Zhou, David Ord, Sidne Omori, Thomas Tedder] CD19 is a B lymphocyte cell-surface marker that is expressed early during pre-B-cell differentiation with expression persisting until terminal differentiation into palsma cells. CD19 is a member of Ig gnee superfamily with two extreacellular Ig-like domains separated amino acid cytoplasmic domain. In this study, Southern blot analysis revelaed that the human and mouse CD19 genes were compact single copy genes. Both the human and mouse CD19 genes were isolated and the nucleotide sequences flanking each exon were determined. Both genes were composed of 15 exons and spanned ∼8 kilobases (kb) of DNA in human and ∼6 kb in mouse. The positions of exon-intron boundaries were identical between human and mouse and correlated with the putative functional domains of the CD19 protein. The 200 bp region 5′ of the putative translation initiation AUG codon as well conserved in sequence between human and mouse and contained potential trasncription regulatory elements. In addition, the 3′ untranslated regions (UT) of the CD19 genes following the termination codon were conservedf in sequence. The high level conservation of nucleotide sequences between species in all exons and 5′ and 3′ UT suggests that expression of the CD19 gene may be regulated in a similar fashion in human and mouse. Springer-Verlag, 1992 Zhou Liang-Ji Division of Tumor Immunology, Danna-Farber Cancer Institute and Department of Pathology, Harvard Medical School, 44 Binney Street, 02115-6084, Boston, MA, USA aut Ord David Division of Tumor Immunology, Danna-Farber Cancer Institute and Department of Pathology, Harvard Medical School, 44 Binney Street, 02115-6084, Boston, MA, USA aut Omori Sidne Depart of Microbiology and Immnunology, Scool of Medicine, University of California Los Angeles, 900024-1570, Los Angeles, CA, USA aut Tedder Thomas Division of Tumor Immunology, Danna-Farber Cancer Institute and Department of Pathology, Harvard Medical School, 44 Binney Street, 02115-6084, Boston, MA, USA aut Immunogenetics Springer-Verlag 35/2(1992-01-01), 102-111 0093-7711 35:2<102 1992 35 251 https://doi.org/10.1007/BF00189519 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00189519 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zhou Liang-Ji Division of Tumor Immunology, Danna-Farber Cancer Institute and Department of Pathology, Harvard Medical School, 44 Binney Street, 02115-6084, Boston, MA, USA aut NATIONALLICENCE 700 1- Ord David Division of Tumor Immunology, Danna-Farber Cancer Institute and Department of Pathology, Harvard Medical School, 44 Binney Street, 02115-6084, Boston, MA, USA aut NATIONALLICENCE 700 1- Omori Sidne Depart of Microbiology and Immnunology, Scool of Medicine, University of California Los Angeles, 900024-1570, Los Angeles, CA, USA aut NATIONALLICENCE 700 1- Tedder Thomas Division of Tumor Immunology, Danna-Farber Cancer Institute and Department of Pathology, Harvard Medical School, 44 Binney Street, 02115-6084, Boston, MA, USA aut NATIONALLICENCE 773 0- Immunogenetics Springer-Verlag 35/2(1992-01-01), 102-111 0093-7711 35:2<102 1992 35 251 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer