caa a22 4500 469033142 CHVBK 20180323132749.0 cr unu---uuuuu 170328e19921001xx s 000 0 eng 10.1007/BF00223542 doi (NATIONALLICENCE)springer-10.1007/BF00223542 Evolution of the major histocompatibility complex: a hundred-fold amplification of MHC class I genes in the African pigmy mouse Nannomys setulosus [Elektronische Daten] [Christiane Delarbre, Christian Jaulin, Philippe Kourilsky, Gabriel Gachelin] The genome of the African murine rodent Nannomys setulosus was found to harbor several thousand major histocompatibility complex (MHC) class I genes instead of the 30-40 genes found in conventional laboratory mice, which are mostly of Mus musculus domesticus origin. Other genes of N. setulosus, either functionally or physically linked to class I genes, are not amplified. Amplified genes derive from as few as three ancestors and amplification has likely occured after the divergence of the two Nannomys species, N. setulosus and N. minutoides, which took place about three million years ago. Amplified genes are mostly pseudogenes. Statistical analysis of dinucleotide frequencies leads us to propose that inactivation of the genes has occured through the repeat induced mutation process, a possible "newcomer” in the evolution of the MHC. Springer-Verlag, 1992 Delarbre Christiane Unité de Biologie Moléculaire du Gène, Unité INSERM 277, Institut Pasteur, 25 rue du Docteur Roux, F-75015, Paris, France aut Jaulin Christian Unité de Biologie Moléculaire du Gène, Unité INSERM 277, Institut Pasteur, 25 rue du Docteur Roux, F-75015, Paris, France aut Kourilsky Philippe Unité de Biologie Moléculaire du Gène, Unité INSERM 277, Institut Pasteur, 25 rue du Docteur Roux, F-75015, Paris, France aut Gachelin Gabriel Unité de Biologie Moléculaire du Gène, Unité INSERM 277, Institut Pasteur, 25 rue du Docteur Roux, F-75015, Paris, France aut Immunogenetics Springer-Verlag 37/1(1992-10-01), 29-38 0093-7711 37:1<29 1992 37 251 https://doi.org/10.1007/BF00223542 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00223542 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Delarbre Christiane Unité de Biologie Moléculaire du Gène, Unité INSERM 277, Institut Pasteur, 25 rue du Docteur Roux, F-75015, Paris, France aut NATIONALLICENCE 700 1- Jaulin Christian Unité de Biologie Moléculaire du Gène, Unité INSERM 277, Institut Pasteur, 25 rue du Docteur Roux, F-75015, Paris, France aut NATIONALLICENCE 700 1- Kourilsky Philippe Unité de Biologie Moléculaire du Gène, Unité INSERM 277, Institut Pasteur, 25 rue du Docteur Roux, F-75015, Paris, France aut NATIONALLICENCE 700 1- Gachelin Gabriel Unité de Biologie Moléculaire du Gène, Unité INSERM 277, Institut Pasteur, 25 rue du Docteur Roux, F-75015, Paris, France aut NATIONALLICENCE 773 0- Immunogenetics Springer-Verlag 37/1(1992-10-01), 29-38 0093-7711 37:1<29 1992 37 251 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer